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Invitrogen

MYO5A Polyclonal Antibody

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MYO5A Polyclonal Antibody

Product Details

PA5-101689

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human MYO5A(Accession Q9Y4I1), corresponding to amino acid residues L1783-P1833.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2851123

Product Specific Information

Antibody detects endogenous levels of total MYO5A.

Target Information

This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: actin-associated molecular motor; alternatively spliced; molecular motor; dilute lethal-20J protein; dilute myosin heavy chain, non-muscle; dilute-opisthotonus; flailer; motor protein; myosin 5a; myosin V; myosin VA (heavy chain 12, myoxin); myosin, heavy polypeptide kinase; myosin-12; myosin-Va; myoxin; OTTMUSP00000017756; OTTMUSP00000019176; OTTMUSP00000046608; unnamed protein product

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Gene Aliases: 9630007J19Rik; d; d-120J; Dbv; Dop; flail; flr; GS1; MVa; MYH12; MYO5; MyoVA; MYR12; Sev-1

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UniProt ID: (Human) Q9Y4I1, (Mouse) Q99104, (Rat) Q9QYF3

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Entrez Gene ID: (Human) 4644, (Mouse) 17918, (Rat) 25017

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Function(s)
microfilament motor activity RNA binding motor activity catalytic activity protein binding ATP binding ATPase activity small GTPase binding actin filament binding SNARE binding actin binding calcium ion binding calmodulin binding enzyme binding protein kinase binding identical protein binding ATP-dependent protein binding macromolecular complex binding calcium-dependent protein binding disordered domain specific binding
Process(es)
melanin metabolic process exocytosis post-Golgi vesicle-mediated transport endocytosis actin filament organization chemical synaptic transmission visual perception protein transport vesicle-mediated transport macroautophagy regulation of exocytosis phenol-containing compound metabolic process actin filament-based movement vesicle transport along actin filament insulin secretion melanocyte differentiation locomotion involved in locomotory behavior secretory granule localization melanosome localization melanosome transport cellular response to insulin stimulus negative regulation of dopamine secretion dopamine metabolic process melanin biosynthetic process odontogenesis myelination long-chain fatty acid biosynthetic process pigmentation developmental pigmentation hair follicle maturation synapse organization endoplasmic reticulum localization establishment of vesicle localization negative regulation of synaptic transmission, glutamatergic protein-containing complex assembly protein localization to plasma membrane establishment of endoplasmic reticulum localization to postsynapse regulation of postsynaptic cytosolic calcium ion concentration axo-dendritic protein transport reactive gliosis positive regulation of cellular response to insulin stimulus positive regulation of protein localization to plasma membrane positive regulation of vascular associated smooth muscle cell migration positive regulation of cytochrome-c oxidase activity regulation of Golgi organization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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