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Invitrogen
PTGIS Polyclonal Antibody
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FIGURE: 1 / 3
PTGIS Antibody (PA5-102017) in IHC (P)
Immunohistochemistry analysis of PTGIS in rat skin tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PTGIS polyclonal antibody (Product # PA5-102017) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-102017
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PTGIS(Accession Q16647), corresponding to amino acid residues S390-H440.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PTGIS.
Target Information
CYP8A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytochrome P450, family 8, subfamily A, polypeptide 1; hydroperoxy icosatetraenoate dehydratase; MGC126858; MGC126860; prostaglandin I2 (prostacyclin) synthase; prostaglandin I2 synthase; unnamed protein product
Gene Aliases: CYP8; CYP8A1; PGIS; PTGI
UniProt ID: (Human) Q16647, (Rat) Q62969, (Mouse) O35074
Entrez Gene ID: (Human) 5740, (Rat) 25527, (Mouse) 19223
prostaglandin biosynthetic process
response to hypoxia
negative regulation of protein phosphorylation
lipid metabolic process
icosanoid metabolic process
embryo implantation
negative regulation of cell proliferation
positive regulation of gene expression
cyclooxygenase pathway
response to estradiol
positive regulation of peroxisome proliferator activated receptor signaling pathway
vasodilation
response to alkaloid
negative regulation of nitric oxide biosynthetic process
positive regulation of angiogenesis
decidualization
negative regulation of smooth muscle cell proliferation
negative regulation of inflammatory response
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to estradiol stimulus
cellular response to hypoxia
monocarboxylic acid biosynthetic process
apoptotic signaling pathway
positive regulation of execution phase of apoptosis
prostanoid biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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