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Invitrogen
CLN2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-102819
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TPP1(Accession O14773), corresponding to amino acid residues S181-L231.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total TPP1.
Target Information
This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell growth-inhibiting gene 1 protein; ceroid-lipofuscinosis, neuronal 2; CLN 2; GIG 1; GIG1; growth-inhibiting protein 1; lysosomal pepstatin insensitive protease; lysosomal pepstatin-insensitive carboxypeptidase; lysosomal pepstatin-insensitive protease; MGC21297; TPP 1; TPP I; TPP-1; TPP-I; TPPI; tripeptidyl aminopeptidase; tripeptidyl peptidase I; tripeptidyl-peptidase I; unnamed protein product
Gene Aliases: CLN2; GIG1; LPIC; SCAR7; TPP-1; TPP-I
UniProt ID: (Human) O14773, (Mouse) O89023, (Rat) Q9EQV6
Entrez Gene ID: (Human) 1200, (Mouse) 12751, (Rat) 83534
proteolysis
lysosome organization
nervous system development
central nervous system development
protein catabolic process
epithelial cell differentiation
peptide catabolic process
bone resorption
neuromuscular process controlling balance
protein localization to chromosome, telomeric region
lysosomal protein catabolic process
lipid metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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