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DEFA4 Polyclonal Antibody
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FIGURE: 1 / 3
DEFA4 Antibody (PA5-103124) in IHC (P)
Immunohistochemistry analysis of DEFA4 in mouse colorectal tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with DEFA4 polyclonal antibody (Product # PA5-103124) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-103124
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DEFA4(Accession P12838), corresponding to amino acid residues I3-A53.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Defensin alpha 4.
Target Information
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-defensin 4; alpha-defensin, 28; corticostatin; corticostatin HP-4; defensin related cryptdin 4; defensin, alpha 4, corticostatin; defensin, alpha 4, preproprotein; neutrophil defensin 4
Gene Aliases: Crp4; DEF4; Defa28; Defcr4; HNP-4; HP-4; HP4
UniProt ID: (Human) P12838, (Mouse) P28311
Entrez Gene ID: (Human) 1669, (Mouse) 13238
defense response
T cell chemotaxis
antimicrobial humoral response
antibacterial humoral response
antifungal humoral response
killing of cells of other organism
innate immune response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
defense response to fungus
membrane disruption in other organism
antimicrobial humoral immune response mediated by antimicrobial peptide
defense response to bacterium
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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