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Invitrogen

KCNMA1 Polyclonal Antibody

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KCNMA1 Polyclonal Antibody

Product Details

PA5-103145

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human KCNMA1(Accession Q12791), corresponding to amino acid residues S778-L828.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2852515

Product Specific Information

Antibody detects endogenous levels of total MaxiK alpha.

Target Information

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: big potassium channel alpha subunit; BK channel; BK channel alpha subunit; BKCA alpha subunit; calcium-activated potassium channel alpha subunit; calcium-activated potassium channel, subfamily M subunit alpha-1; gp90; env; k(VCA)alpha; maxi K channel; maxi K channel; KCNMA1; maxi-K channel HSLO; maxi-k channel isoform; MaxiK alpha subunit; mSlo; potassium channel; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium ion channel; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; slo; slo homolog; slowpoke homolog; splice variant; stretch-activated Kca channel; unnamed protein product; voltage-sensitive calcium channel

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Gene Aliases: 5730414M22Rik; bA205K10.1; BKCa; BKCA alpha; BKTM; CADEDS; cbv1; hSlo; IEG16; k(VCA)alpha; KCa1.1; Kcnma; KCNMA1b; KCNMA1c; LIWAS; MaxiK; mSlo; mSLO1; PNKD3; SAKCA; SLO; SLO-ALPHA; SLO1

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UniProt ID: (Human) Q12791, (Mouse) Q08460, (Rat) Q62976

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Entrez Gene ID: (Human) 3778, (Mouse) 16531, (Rat) 83731

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Function(s)
actin binding ion channel activity voltage-gated potassium channel activity protein binding calcium-activated potassium channel activity identical protein binding large conductance calcium-activated potassium channel activity potassium channel activity macromolecular complex binding ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
Process(es)
response to hypoxia ion transport potassium ion transport response to osmotic stress chemical synaptic transmission sensory perception of sound circadian rhythm adult walking behavior response to pH neuronal action potential cellular potassium ion homeostasis regulation of aldosterone metabolic process response to carbon monoxide vasodilation regulation of membrane potential auditory receptor cell differentiation positive regulation of apoptotic process positive regulation of neuron apoptotic process response to estrogen locomotor rhythm negative regulation of cell volume negative regulation of smooth muscle contraction saliva secretion cell maturation neuromuscular process controlling balance response to calcium ion transmembrane transport micturition eye blink reflex smooth muscle contraction involved in micturition relaxation of vascular smooth muscle potassium ion transmembrane transport regulation of blood vessel diameter regulation of presynaptic membrane potential negative regulation of small intestine smooth muscle contraction positive regulation of membrane hyperpolarization
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