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          • Primary Antibodies ›
          • SOX8/SOX9/SOX17/SOX18 Antibodies

          Invitrogen

          SOX8/SOX9/SOX17/SOX18 Polyclonal Antibody

          View all (2) SOX8/SOX9/SOX17/SOX18 antibodies

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          Cite SOX8/SOX9/SOX17/SOX18 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (2)
          SOX8/SOX9/SOX17/SOX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          SOX8/SOX9/SOX17/SOX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

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          SOX8/SOX9/SOX17/SOX18 Antibody (PA5-103253) in IHC (P)

          Immunohistochemistry analysis of paraffin-embedded SOX8/SOX9/SOX17/SOX18 in rat kidney tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with SOX8/SOX9/SOX17/SOX18 polyclonal antibody (Product # PA5-103253) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          SOX8/SOX9/SOX17/SOX18 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          SOX8/SOX9/SOX17/SOX18 Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          SOX8/SOX9/SOX17/SOX18 Polyclonal Antibody

          Product Details

          PA5-103253

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000-1:3,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -

          Immunocytochemistry (ICC/IF)

          1:100-1:500
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthesized peptide derived from human SOX8(Accession P57073), corresponding to amino acid residues K103-E153.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2852616

          Product Specific Information

          Antibody detects endogenous levels of total SOX8/9/17/18.

          Target Information

          Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: ragged; SOX18; SOX9; SRY (sex determining region Y)-box 17; SRY (sex determining region Y)-box 18; SRY (sex determining region Y)-box 8; SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal); SRY (sex determining region Y)-box9; SRY (sex-determining region Y)-box 9 protein; SRY box 17; SRY box 18; SRY box 8; SRY box 9; SRY-box 17; SRY-box 18; SRY-box 8; SRY-box 9; SRY-box containing gene 17; SRY-box containing gene 18; SRY-box containing gene 8; SRY-box containing gene 9; Sry-related HMG-box gene 18; SRY-related HMG-box transcription factor SOX17; SRY-related HMG-box, gene 9; unnamed protein product

          View more View less

          Gene Aliases: 2010306G03Rik; CMD1; CMPD1; ENH13; HLTRS; HLTS; mKIAA4243; mSox9; PPH7; Ra; Ragl; SRA1; SRXX2; SRXY10; SRY; TESCO; VUR3

          View more View less

          UniProt ID: (Human) Q9H6I2, (Human) P35713, (Human) P57073, (Human) P48436, (Mouse) Q61473, (Mouse) P43680, (Mouse) Q04886, (Rat) F1LYL9, (Mouse) Q04887

          View more View less

          Entrez Gene ID: (Human) 64321, (Human) 54345, (Human) 30812, (Human) 6662, (Mouse) 20671, (Rat) 312936, (Mouse) 20672, (Rat) 311723, (Mouse) 20681, (Rat) 302993, (Rat) 140586, (Mouse) 20682

          View more View less

          Function(s)
          transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding core promoter proximal region sequence-specific DNA binding DNA-binding transcription factor binding chromatin binding protein kinase A catalytic subunit binding bHLH transcription factor binding pre-mRNA intronic binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter angiogenesis vasculogenesis vasculature development lymphangiogenesis heart looping outflow tract morphogenesis tissue development hair cycle process embryonic heart tube development blood vessel endothelial cell migration negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter anatomical structure formation involved in morphogenesis endocardium formation lymphatic endothelial cell differentiation endocardial cell differentiation establishment of endothelial barrier skeletal system development cartilage condensation ossification branching involved in ureteric bud morphogenesis cell fate specification epithelial to mesenchymal transition tissue homeostasis positive regulation of protein phosphorylation hair follicle development morphogenesis of an epithelium positive regulation of mesenchymal cell proliferation chondrocyte differentiation chondrocyte development negative regulation of immune system process heart valve development heart valve morphogenesis aortic valve morphogenesis heart valve formation endocardial cushion morphogenesis chondrocyte differentiation involved in endochondral bone morphogenesis chondrocyte hypertrophy growth plate cartilage chondrocyte growth nucleosome assembly chromatin remodeling regulation of transcription from RNA polymerase II promoter cytoskeleton organization signal transduction epidermal growth factor receptor signaling pathway Notch signaling pathway spermatogenesis central nervous system development heart development positive regulation of cell proliferation negative regulation of cell proliferation male gonad development gene expression regulation of gene expression regulation of cell cycle process positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial cell migration neural crest cell development male germ-line sex determination cell differentiation regulation of cell adhesion extracellular matrix organization male sex determination negative regulation of ossification negative regulation of bone mineralization prostate gland development negative regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation mammary gland development notochord development otic vesicle formation endocrine pancreas development negative regulation of chondrocyte differentiation positive regulation of chondrocyte differentiation lacrimal gland development protein localization to nucleus somatic stem cell population maintenance intrahepatic bile duct development regulation of cell proliferation regulation of apoptotic process negative regulation of apoptotic process cell fate commitment regulation of cell differentiation negative regulation of myoblast differentiation negative regulation of osteoblast differentiation positive regulation of protein catabolic process negative regulation of fatty acid oxidation negative regulation of photoreceptor cell differentiation oligodendrocyte differentiation homeostasis of number of cells within a tissue positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation cartilage development Sertoli cell differentiation Sertoli cell development astrocyte fate commitment retina development in camera-type eye limb bud formation retinal rod cell differentiation endochondral bone morphogenesis epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation prostate gland morphogenesis epithelial cell proliferation involved in prostatic bud elongation bronchus cartilage development trachea cartilage development intestinal epithelial structure maintenance regulation of cell proliferation involved in tissue homeostasis positive regulation of cartilage development regulation of branching involved in lung morphogenesis morphogenesis of a branching epithelium lung smooth muscle development protein-containing complex assembly negative regulation of biomineral tissue development ERK1 and ERK2 cascade Harderian gland development response to fatty acid cellular response to mechanical stimulus cellular response to retinoic acid cellular response to interleukin-1 cellular response to epidermal growth factor stimulus cellular response to heparin cellular response to transforming growth factor beta stimulus otic vesicle development renal vesicle induction metanephric tubule development ureter development ureter urothelium development ureter smooth muscle cell differentiation ureter morphogenesis metanephric nephron tubule formation negative regulation of canonical Wnt signaling pathway cochlea morphogenesis positive regulation of kidney development positive regulation of branching involved in ureteric bud morphogenesis anterior head development cell-cell adhesion positive regulation of extracellular matrix assembly positive regulation of chondrocyte proliferation negative regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of beta-catenin-TCF complex assembly positive regulation of male gonad development positive regulation of cell proliferation involved in heart morphogenesis positive regulation of mesenchymal stem cell differentiation regulation of epithelial cell proliferation involved in lung morphogenesis negative regulation of mesenchymal cell apoptotic process osteoblast differentiation in utero embryonic development neural crest cell migration peripheral nervous system development regulation of hormone levels positive regulation of gliogenesis positive regulation of osteoblast proliferation skeletal muscle cell differentiation fat cell differentiation cell maturation enteric nervous system development adipose tissue development metanephros development endoderm formation endodermal cell fate specification cardiogenic plate morphogenesis embryonic heart tube morphogenesis regulation of transcription, DNA-templated endoderm development negative regulation of Wnt signaling pathway negative regulation of cell growth protein destabilization response to alkaloid regulation of embryonic development embryonic foregut morphogenesis protein stabilization cardiac cell fate determination heart formation endodermal digestive tract morphogenesis regulation of cardiac cell fate specification neural crest cell fate specification cellular response to BMP stimulus inner cell mass cellular morphogenesis gastrulation endodermal cell fate determination rostrocaudal neural tube patterning signal transduction involved in regulation of gene expression cell migration involved in gastrulation positive regulation of cell differentiation embryonic organ development stem cell differentiation stem cell fate specification common bile duct development gall bladder development regulation of stem cell proliferation cellular response to leukemia inhibitory factor regulation of stem cell division biological_process blood vessel development lymph vessel development
          It has to be done as per old AB suggested Products section.

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