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Invitrogen

NKX3.1 Polyclonal Antibody

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NKX3.1 Polyclonal Antibody

Product Details

PA5-104460

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NKX3-1(Accession Q99801), corresponding to amino acid residues E94-S144.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2853761

Product Specific Information

Antibody detects endogenous levels of total NKX3.1.

Target Information

The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Drosophila NK-3 transcription factor, locus 1; homeobox protein NK-3 homolog A; NK homeobox, family 3, A; NK-3 transcription factor, locus 1; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1; NKX3-1 antibody; prostate-specific ag; unnamed protein product

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Gene Aliases: bagpipe; BAPX2; Bax; Nkx-3.1; NKX3; NKX3.1; NKX3A

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UniProt ID: (Human) Q99801, (Mouse) P97436

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Entrez Gene ID: (Human) 4824, (Mouse) 18095

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding cysteine-type endopeptidase activator activity involved in apoptotic process estrogen receptor binding histone deacetylase binding sequence-specific DNA binding MADS box domain binding DNA-binding transcription factor binding transcription regulator inhibitor activity sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter urogenital system development metanephros development somitogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process cellular response to DNA damage stimulus salivary gland development heart development positive regulation of cell proliferation negative regulation of cell proliferation male gonad development regulation of signal transduction positive regulation of gene expression negative regulation of gene expression cell differentiation androgen receptor signaling pathway prostate gland development regulation of protein localization response to testosterone response to lipid internal genitalia morphogenesis dorsal aorta development regulation of cell proliferation negative regulation of insulin-like growth factor receptor signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter branching morphogenesis of an epithelial tube negative regulation of epithelial cell proliferation regulation of multicellular organismal process positive regulation of cell division positive regulation of protein kinase B signaling pharyngeal system development branching involved in prostate gland morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis negative regulation of epithelial cell proliferation involved in prostate gland development cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to steroid hormone stimulus cellular response to hypoxia cellular response to xenobiotic stimulus positive regulation of androgen secretion positive regulation of intrinsic apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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