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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Antibody detects endogenous levels of fragment of activated IL-1 beta resulting from cleavage adjacent to Asp116.
IL-1 beta (Cleaved Asp116) refers to the mature, biologically active form of interleukin-1 beta generated after proteolytic processing of its inactive precursor, pro-IL-1 beta. IL-1 beta is encoded by the IL1B gene and is synthesized as a 31 kDa cytosolic precursor in response to inflammatory stimuli such as infection or tissue injury. Activation of inflammasome complexes leads to caspase-1-mediated cleavage at aspartic acid residue 116, producing the approximately 17 kDa mature cytokine. The cleaved form is released through non-classical secretion pathways and binds to the interleukin-1 receptor type 1 (IL-1R1), triggering downstream signaling through NF-kappa B and MAP kinase pathways. Mature IL-1 beta is a potent pro-inflammatory cytokine that promotes fever, leukocyte recruitment, and amplification of innate and adaptive immune responses. Detection of IL-1 beta cleaved at Asp116 is widely used as a marker of inflammasome activation and inflammatory signaling in immunology and disease research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: catabolin; Cleaved IL-1 beta; IL-1; IL-1 beta; IL1B; interleukin 1 precursor polypeptide; interleukin 1b; interleukin 1beta; interlukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta; unnamed protein product
Gene Aliases: IL-1; Il-1b; IL-1beta; IL-1F2; il1-b; IL1-BETA; IL1beta; IL1F2; zgc:111873
UniProt ID: (Human) P01584, (Mouse) P10749
Entrez Gene ID: (Human) 3553, (Rat) 24494, (Mouse) 16176, (Zebrafish) 405770
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