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Invitrogen
Phospho-WWC1 (Ser947) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-WWC1 (Ser947) Antibody (PA5-105068) in WB
Western blot analysis of Phospho-WWC1 (Ser947) in 293T cell lysate (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-WWC1 (Ser947) polyclonal antibody (Product # PA5-105068).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105068
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human WWC1(Accession Q8IX03), corresponding to amino acid residues around phosphorylated Ser947.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of KIBRA only when phosphorylated at Ser947.
Target Information
WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway. This pathway plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. WWC1, along with NF2, can synergistically induce the phosphorylation of LATS1 and LATS2. It acts as a transcriptional coactivator of ESR1 - which plays an essential role in DYNLL1-mediated ESR1 transactivation. WWC1 also functions as a regulatior of collagen-stimulated activation of the ERK/MAPK cascade.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytosolic WW domain-containing protein; FLJ10865; FLJ23369; HBeAg-binding protein 3; HBebp36; kidney and brain protein; protein phosphatase 1, regulatory subunit 168; protein WWC1; unnamed protein product; WW domain-containing protein 1; WW, C2 and coiled-coil domain containing 1
Gene Aliases: HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168; RGD1308329
UniProt ID: (Human) Q8IX03, (Mouse) Q5SXA9
Entrez Gene ID: (Human) 23286, (Rat) 303039, (Mouse) 211652
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
negative regulation of cell proliferation
cell migration
hippo signaling
regulation of hippo signaling
negative regulation of hippo signaling
positive regulation of MAPK cascade
positive regulation of transcription, DNA-templated
negative regulation of organ growth
establishment of cell polarity
positive regulation of hippo signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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