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Invitrogen

Phospho-LRP5 (Tyr1473) Polyclonal Antibody

View all (14) LRP5 antibodies

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Phospho-LRP5 (Tyr1473) Polyclonal Antibody

Product Details

PA5-105096

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human LRP5(Accession O75197), corresponding to amino acid residues around phosphorylated Tyr1473.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816569

Product Specific Information

Antibody detects endogenous levels of LRP5 only when phosphorylated at Tyr1473.

Target Information

LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HGNC:6697; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; low-density lipoprotein receptor-related protein 7; LRP-5; LRP-7; LRP5; unnamed protein product

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Gene Aliases: BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7; LRP7; mKIAA4142; OPPG; OPS; OPTA1; PCLD4; VBCH2

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UniProt ID: (Human) O75197, (Mouse) Q91VN0

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Entrez Gene ID: (Human) 4041, (Rat) 293649, (Mouse) 16973

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Function(s)
protein binding coreceptor activity Wnt-protein binding toxin transporter activity Wnt-activated receptor activity
Process(es)
gastrulation with mouth forming second vasculature development positive regulation of mesenchymal cell proliferation osteoblast development glucose catabolic process amino acid transport cell-cell signaling nervous system development cholesterol metabolic process regulation of blood pressure positive regulation of cell proliferation anterior/posterior pattern specification gene expression Wnt signaling pathway positive regulation of osteoblast proliferation somatic stem cell population maintenance limb morphogenesis extracellular matrix-cell signaling cell migration involved in gastrulation cholesterol homeostasis embryonic digit morphogenesis regulation of apoptotic process response to peptide hormone positive regulation of fat cell differentiation negative regulation of osteoblast differentiation positive regulation of osteoblast differentiation positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter bone remodeling blood vessel morphogenesis bone marrow development anatomical structure regression retina morphogenesis in camera-type eye canonical Wnt signaling pathway bone development bone morphogenesis branching involved in mammary gland duct morphogenesis mammary gland duct morphogenesis adipose tissue development establishment of blood-brain barrier regulation of insulin secretion involved in cellular response to glucose stimulus retina vasculature development in camera-type eye retina vasculature morphogenesis in camera-type eye retinal blood vessel morphogenesis cell-cell adhesion Norrin signaling pathway apoptotic process involved in patterning of blood vessels positive regulation of skeletal muscle acetylcholine-gated channel clustering establishment of blood-retinal barrier organ morphogenesis tissue development positive regulation of cell differentiation regulation of osteoblast differentiation positive regulation of cell cycle
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