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Invitrogen

Phospho-PKA alpha/beta/gamma (Thr198) Polyclonal Antibody

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View all (5) PKA alpha/beta/gamma antibodies

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Product Details

PA5-105515

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PRKACA(Accession P17612), corresponding to amino acid residues around phosphorylated Thr198.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816943

Product Specific Information

Antibody detects endogenous levels of PKA alpha/beta/gamma CAT only when phosphorylated at Thr198.

Target Information

Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation and behavior. PKA is composed of two catalytic (PKAc; Protein Kinase A catalytic subunit) and two regulatory subunits (PKAr). Upon binding cAMP, the complex dissociates to PKAr dimer and two activated PKAc ser/thr protein kinase catalytic monomers. The released PKAc can translocate into the nucleus and exert a regulatory role in the activation of multiple nuclear hormone receptors. However, PKAc-mediated activation of tonicity-dependent gene expression is cAMP independent. Humans express three types of PKAc subunit - PKAc alpha is present in most human tissues, PKAc beta and gamma are tissue-specific, the later is found in testes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: C-alpha-s; alternatively spliced isoform; cAMP-dependent protein kinase C beta; cAMP-dependent protein kinase catalytic subunit C alpha; Cbeta2 PKA; Cs-PKA; PKA C-alpha; PKA C-beta; PKA C-gamma; protein kinase A; protein kinase A catalytic subunit; protein kinase A catalytic subunit beta; protein kinase, cAMP dependent, catalytic, beta; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, beta catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha; protein kinase, cAMP-dependent, catalytic, beta; protein kinase, cAMP-dependent, catalytic, gamma; protein kinase, cAMP-dependent, gamma catalytic subunit; serine(threonine) protein kinase; sperm cAMP-dependent protein kinase catalytic subunit; unnamed protein product

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Gene Aliases: BDPLT19; CAFD1; CAFD2; CbPKA; Cs-PKA; KAPG; PKA C-beta; PKACA; PKACB; PKACg; PKCA1; PKCD; PPNAD4

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UniProt ID: (Human) P17612, (Human) P22694, (Human) P22612, (Mouse) P05132, (Mouse) P68181, (Rat) P68182

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Entrez Gene ID: (Human) 5566, (Human) 5567, (Human) 5568, (Mouse) 18747, (Rat) 25636, (Mouse) 18749, (Rat) 293508

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Function(s)
magnesium ion binding protein kinase activity protein serine/threonine kinase activity cAMP-dependent protein kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding potassium channel inhibitor activity protein kinase binding protein domain specific binding manganese ion binding protein kinase A regulatory subunit binding channel activator activity protein serine kinase activity histone H1-4S35 kinase activity small GTPase binding ubiquitin protein ligase binding macromolecular complex binding cyclic nucleotide-dependent protein kinase activity
Process(es)
renal water homeostasis adenylate cyclase-activating G-protein coupled receptor signaling pathway spermatogenesis male gonad development positive regulation of insulin secretion high-density lipoprotein particle assembly vascular endothelial cell response to laminar fluid shear stress neural tube closure protein phosphorylation adenylate cyclase-modulating G-protein coupled receptor signaling pathway cellular response to nutrient levels TORC1 signaling negative regulation of smoothened signaling pathway negative regulation of meiotic cell cycle regulation of protein processing negative regulation of TORC1 signaling mesoderm formation chromatin remodeling mRNA processing adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway positive regulation of cell proliferation positive regulation of triglyceride catabolic process peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cellular potassium ion homeostasis cellular response to heat insulin secretion involved in cellular response to glucose stimulus interleukin-2-mediated signaling pathway regulation of cellular respiration positive regulation of cholesterol biosynthetic process regulation of osteoblast differentiation positive regulation of gluconeogenesis negative regulation of glycolytic process protein autophosphorylation positive regulation of protein export from nucleus sperm capacitation spontaneous exocytosis of neurotransmitter positive regulation of phagocytosis modulation of synaptic transmission regulation of cell cycle regulation of synaptic transmission, glutamatergic regulation of proteasomal protein catabolic process cellular response to cold regulation of microtubule cytoskeleton organization cellular response to glucose stimulus cellular response to parathyroid hormone stimulus cellular response to glucagon stimulus postsynaptic modulation of chemical synaptic transmission negative regulation of protein localization to chromatin cAMP/PKA signal transduction positive regulation of protein localization to plasma membrane negative regulation of glycolytic process through fructose-6-phosphate protein localization to lipid particle regulation of bicellular tight junction assembly negative regulation of meiotic cell cycle process involved in oocyte maturation regulation of heart rate regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of macroautophagy cytokine-mediated signaling pathway negative regulation of interleukin-2 production mitochondrial protein catabolic process positive regulation of calcium-mediated signaling regulation of cardiac muscle contraction cellular response to epinephrine stimulus cell communication by electrical coupling involved in cardiac conduction regulation of cardiac conduction signal transduction
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