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Invitrogen

Phospho-CaMKII alpha/beta/delta (Ser235) Polyclonal Antibody

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Phospho-CaMKII alpha/beta/delta (Ser235) Polyclonal Antibody

Product Details

PA5-105641

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CAMK2B(Accession Q13554), corresponding to amino acid residues around phosphorylated Ser235.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817069

Product Specific Information

Antibody detects endogenous levels of CaMKII only when phosphorylated at Ser235.

Target Information

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be co-expressed in the same tissue type. CaMKII alpha is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha CaM kinase II; alpha-CaMKII; alpha-KAP; alternatively spliced; association domain; beta M CaM kinase II; brain type II Ca2+/calmodulin-dependent protein kinase beta subunit; Ca++/calmodulin-dependent protein kinase 2 delta subunit; Ca++/calmodulin-dependent protein kinase II beta subunit; Ca++/calmodulin-dependent protein kinase II, delta subunit; Ca2+/calmodulin-dependent protein kinase II alpha; Calci; Calcium, calmodulin-dependent protein kinase II; Calcium, calmodulin-dependent protein kinase, type II; calcium-calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II delta chain; calmodulin-dependent protein kinase II-delta (EC 2.7.1.37); CaM kinase II; CaM kinase II alpha subunit; CaM kinase II beta subunit; CaM kinase II delta subunit; caM kinase II subunit alpha; caM kinase II subunit beta; caM kinase II subunit delta; CaM-kinase II alpha chain; CaM-kinase II beta chain; CaM-kinase II delta chain; CAMK; CaMK II; CaMK-2 delta; CaMK-2a; CAMK-II; CaMK-II alpha subunit; CaMK-II delta subunit; caMK-II subunit alpha; caMK-II subunit beta; caMK-II subunit delta; CaMK2 delta; CaMK2- delta; CaMK2-a; CAMK2G; CAMKG; proline rich calmodulin-dependent protein kinase; protein kinase homolog; unnamed protein product

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Gene Aliases: 2810011D23Rik; 8030469K03Rik; [d]-CaMKII; CAM2; CaMK II; CAMK1; CAMK2; CAMKA; CAMKB; CAMKD; Camki; CaMKII; CaMKIIalpha; CaMKIIbeta; CaMKIINalpha; Ck2b; mKIAA0968; MRD53; MRD54; MRT63; PK2CDD; PKCCD; RATCAMKI

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UniProt ID: (Human) Q9UQM7, (Human) Q13554, (Human) Q13557, (Mouse) P11798, (Rat) P11275, (Rat) P08413, (Mouse) P28652, (Rat) P15791, (Mouse) Q6PHZ2

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Entrez Gene ID: (Human) 815, (Human) 816, (Human) 817, (Mouse) 12322, (Rat) 25400, (Rat) 24245, (Mouse) 12323, (Rat) 24246, (Mouse) 108058

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Function(s)
protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity protein binding calmodulin binding ATP binding glutamate receptor binding identical protein binding protein homodimerization activity protein serine kinase activity sodium channel inhibitor activity titin binding ion channel binding kinase activity GTPase activating protein binding protein kinase binding phospholipase binding structural constituent of postsynaptic actin cytoskeleton nitric-oxide synthase binding
Process(es)
regulation of cell growth regulation of the force of heart contraction regulation of membrane depolarization regulation of transcription from RNA polymerase II promoter protein phosphorylation regulation of heart contraction positive regulation of cardiac muscle hypertrophy regulation of cell communication by electrical coupling positive regulation of cardiac muscle cell apoptotic process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion endoplasmic reticulum calcium ion homeostasis regulation of neuronal synaptic plasticity relaxation of cardiac muscle long-term synaptic potentiation regulation of ryanodine-sensitive calcium-release channel activity regulation of cellular localization cellular response to calcium ion cardiac muscle cell contraction regulation of heart rate by cardiac conduction regulation of cardiac muscle cell action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of cell communication by electrical coupling involved in cardiac conduction regulation of relaxation of cardiac muscle negative regulation of sodium ion transmembrane transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel regulation of protein localization to plasma membrane G1/S transition of mitotic cell cycle response to ischemia calcium ion transport JAK-STAT cascade peptidyl-serine phosphorylation ionotropic glutamate receptor signaling pathway cellular response to interferon-beta angiotensin-activated signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JAK-STAT cascade protein autophosphorylation regulation of neurotransmitter secretion dendrite morphogenesis positive regulation of calcium ion transport dendritic spine development cellular response to interferon-gamma regulation of neurotransmitter receptor localization to postsynaptic specialization membrane neurotransmitter receptor transport to plasma membrane negative regulation of ferroptosis regulation of mitochondrial membrane permeability involved in apoptotic process peptidyl-threonine autophosphorylation regulation of endocannabinoid signaling pathway regulation of neuron migration inhibitory G-protein coupled receptor phosphorylation positive regulation of phospholipase activity positive regulation of neuron projection development regulation of synaptic transmission, cholinergic response to cadmium ion regulation of long-term neuronal synaptic plasticity neuromuscular process controlling balance activation of meiosis involved in egg activation positive regulation of dendritic spine morphogenesis regulation of synapse maturation positive regulation of synapse maturation postsynaptic actin cytoskeleton organization hippocampal neuron apoptotic process cellular response to homocysteine response to psychosocial stress positive regulation of apoptotic signaling pathway signal transduction regulation of skeletal muscle adaptation regulation of synapse structural plasticity regulation of calcium ion transport regulation of dendritic spine development response to hypoxia regulation of sodium ion transport positive regulation of G2/M transition of mitotic cell cycle positive regulation of smooth muscle cell migration cellular potassium ion homeostasis positive regulation of Rac protein signal transduction cardiac muscle contraction cell growth involved in cardiac muscle cell development positive regulation of ERK1 and ERK2 cascade positive regulation of vascular smooth muscle cell proliferation positive regulation of DNA biosynthetic process
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