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Invitrogen

Phospho-VEGF Receptor 2 (Tyr996) Polyclonal Antibody

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View all (100) FLK1 (VEGF Receptor 2) antibodies

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Phospho-VEGF Receptor 2 (Tyr996) Polyclonal Antibody

Product Details

PA5-105765

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (IHC)

-
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human KDR(Accession P35968), corresponding to amino acid residues around phosphorylated Tyr996.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817164

Product Specific Information

Antibody detects endogenous levels of VEGFR2 only when phosphorylated at Tyr996.

Target Information

KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD309 antigen; fetal liver kinase 1; fetal liver kinase-1; FLK-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); kinase insert domain protein receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); kinase NYK; platelet-derived growth factor receptor-related tyrosine kinase; protein-tyrosine kinase receptor Flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; soluble VEGFR2; tyrosine kinase growth factor receptor; unnamed protein product; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor; VEGF receptor-2; VEGFR-2; tyrosine kinase

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Gene Aliases: 6130401C07; CD309; Flk-1; FLK1; Krd-1; Ly73; orv; sVEGFR-2; VEGFR; VEGFR-2; VEGFR2

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UniProt ID: (Human) P35968, (Rat) O08775, (Mouse) P35918

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Entrez Gene ID: (Human) 3791, (Rat) 25589, (Mouse) 16542

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity integrin binding protein binding ATP binding coreceptor activity growth factor binding vascular endothelial growth factor binding identical protein binding cadherin binding Hsp90 protein binding
Process(es)
angiogenesis patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation vasculature development endocardium development endothelium development transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation regulation of cell shape positive regulation of endothelial cell migration negative regulation of gene expression positive regulation of macroautophagy cell migration peptidyl-tyrosine phosphorylation positive regulation of cell migration positive regulation of BMP signaling pathway embryonic hemopoiesis cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-2 signaling pathway vascular endothelial growth factor signaling pathway negative regulation of apoptotic process regulation of MAPK cascade positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration endothelial cell differentiation positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway positive regulation of positive chemotaxis positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling positive regulation of mitochondrial depolarization epithelial tube morphogenesis vascular wound healing positive regulation of ERK1 and ERK2 cascade semaphorin-plexin signaling pathway positive regulation of cell migration involved in sprouting angiogenesis positive regulation of mitochondrial fission positive regulation of nitric oxide-cGMP mediated signal transduction cellular response to hydrogen sulfide negative regulation of endothelial cell apoptotic process positive regulation of endothelial cell chemotaxis positive regulation of vasculogenesis ovarian follicle development response to hypoxia regulation of endothelial cell proliferation lymph vessel development positive regulation of mesenchymal cell proliferation negative regulation of systemic arterial blood pressure endochondral bone growth positive regulation of cytosolic calcium ion concentration gonad development male gonad development response to xenobiotic stimulus positive regulation of signal transduction hemopoiesis lung development positive regulation of TOR signaling vasodilation surfactant homeostasis cell fate commitment positive regulation of long-term neuronal synaptic plasticity lung alveolus development cell maturation post-embryonic camera-type eye morphogenesis response to axon injury branching morphogenesis of an epithelial tube neuron projection morphogenesis positive regulation of epithelial cell proliferation positive regulation of neurogenesis positive regulation of calcium-mediated signaling calcium ion homeostasis endothelial tube morphogenesis response to oxygen levels regulation of hematopoietic progenitor cell differentiation regulation of bone development positive regulation of vascular endothelial growth factor receptor signaling pathway blood vessel morphogenesis blood vessel endothelial cell differentiation
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