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          • Primary Antibodies ›
          • FGFR Pan Antibodies

          Invitrogen

          Phospho-FGFR Pan (Tyr653, Tyr654) Polyclonal Antibody

          View all (2) FGFR Pan antibodies

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          Cite Phospho-FGFR Pan (Tyr653, Tyr654) Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (6)
          Phospho-FGFR Pan (Tyr653, Tyr654) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Phospho-FGFR Pan (Tyr653, Tyr654) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 6

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          Phospho-FGFR Pan (Tyr653, Tyr654) Antibody (PA5-105938) in IHC (P)

          Immunohistochemistry analysis of paraffin-embedded Phospho-FGFR Pan (Tyr653, Tyr654) in mouse intestinal tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-FGFR Pan (Tyr653, Tyr654) polyclonal antibody (Product # PA5-105938) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbi... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Phospho-FGFR Pan (Tyr653, Tyr654) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-FGFR Pan (Tyr653, Tyr654) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-FGFR Pan (Tyr653, Tyr654) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-FGFR Pan (Tyr653, Tyr654) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-FGFR Pan (Tyr653, Tyr654) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-FGFR Pan (Tyr653, Tyr654) Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          Phospho-FGFR Pan (Tyr653, Tyr654) Polyclonal Antibody

          Product Details

          PA5-105938

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000-1:3,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Non-human primate, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthesized peptide derived from human FGFR1(Accession P11362), corresponding to amino acid residues around phosphorylated Tyr654.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          sequential chromatography

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2817337

          Product Specific Information

          Antibody detects endogenous levels of FGFR1/2/3/4 only when phosphorylated at Tyr653+Tyr654.

          Target Information

          This gene encodes a protein that is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: alternatively spliced; bacteria-expressed kinase; basic fibroblast growth factor receptor 1; BEK fibroblast growth factor receptor; CTLA-2-beta protein; FGF receptor precursor; FGF receptor-1; FGF receptor-1 precursor; fgfr 1; FGFR-3; FGFR-4; FGFR1-IIIb; receptor tyrosine kinase; FGFR1/PLAG1 fusion; FGFR2; FGFR4; FGFR4 isoform; exon 17 splice variant; FGFR4 variant; ptd-FGFR4; fibroblast growth factor receptor (FGFr) transmembrane form; fibroblast growth factor receptor 3-S; fibroblast growth factor receptor 4 16 minus form; fibroblast growth factor receptor FGFR-1 secreted form; fibroblast growth factor-receptor precursor; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; growth factor receptor; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; keratinocyte growth factor receptor; orf 5' of fibroblast growth factor receptor 1 FGFR-1; protein tyrosine kinase, receptor like 14; protein-tyrosine kinase; protein-tyrosine kinase receptor MPK-11; proto-oncogene c-Fgr; receptor tyrosine kinase; soluble form; FGF-R1; transmembrane protein tyrosine kinase; transmembrane receptor; tyrosine kinase; alternatively spliced; tyrosine kinase; tyrosine kinase JTK4; tyrosine kinase receptor; tyrosine kinase related to fibroblast growth factor receptor; tyrosine kynase receptor; tyrosylprotein kinase; unnamed protein product

          View more View less

          Gene Aliases: ACH; BBDS; BEK; bFGF-R; bFGF-R-1; BFGFR; BFR-1; c-fgr; CD331; CD332; CD333; CD334; CEK; CEK2; CEK3; CFD1; Eask; ECCL; ECT1; FGFBR; FGFR-1; Fgfr-2; Fgfr-3; Fgfr-4; Fgfr-7; FGFR-I; Fgfr2b; Fgfr7; FLG; Flg-2; FLT-2; FLT2; Fr1; FR3; HBGFR; HH2; HRTFDS; HSFGFR3EX; Hspy; JTK2; JTK4; JWS; K-SAM; KAL2; KGFR; KGFRTr; MFR; Mfr3; N-SAM; OGD; sam3; svs; TK14; TK25; TKF

          View more View less

          UniProt ID: (Human) P11362, (Human) P21802, (Human) P22607, (Human) P22455, (Mouse) P16092, (Rat) Q04589, (Mouse) P21803, (Mouse) Q03142, (Rat) Q498D6

          View more View less

          Entrez Gene ID: (Human) 2260, (Human) 2263, (Human) 2261, (Human) 2264, (Mouse) 14182, (Rat) 79114, (Mouse) 14183, (Rat) 25022, (Mouse) 14184, (Rat) 84489, (Mouse) 14186, (Rat) 25114

          View more View less

          Function(s)
          protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor-activated receptor activity protein binding ATP binding heparin binding fibroblast growth factor binding identical protein binding protein homodimerization activity receptor-receptor interaction receptor binding SH2 domain binding macromolecular complex binding cell adhesion molecule binding nucleotide binding miRNA binding growth factor activity
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter angiogenesis ureteric bud development in utero embryonic development organ induction epithelial to mesenchymal transition positive regulation of mesenchymal cell proliferation chondrocyte differentiation regulation of mitotic cell cycle brain development salivary gland morphogenesis sensory perception of sound positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway gene expression regulation of gene expression regulation of cell cycle process negative regulation of gene expression positive regulation of cell communication positive regulation of fibroblast migration regulation of phosphate transport positive regulation of neuron projection development peptidyl-tyrosine phosphorylation stem cell population maintenance orbitofrontal cortex development postnatal olfactory bulb interneuron migration ventricular zone neuroblast division forebrain generation of neurons central nervous system neuron development tangential migration from the subventricular zone to the olfactory bulb positive regulation of signaling lung development embryonic limb morphogenesis epithelial cell differentiation midbrain development neuron projection development biomineral tissue development fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development regulation of cell proliferation inner ear morphogenesis outer ear morphogenesis middle ear morphogenesis regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration ear development cellular response to fibroblast growth factor stimulus positive regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation paraxial mesoderm development regulation of lateral mesodermal cell fate specification cell maturation blood vessel morphogenesis generation of neurons mesenchymal cell differentiation regulation of phosphorus metabolic process positive regulation of protein kinase B signaling calcium ion homeostasis positive regulation of cardiac muscle cell proliferation auditory receptor cell development branching involved in salivary gland morphogenesis lung-associated mesenchyme development regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling vasculogenesis involved in coronary vascular morphogenesis vitamin D3 metabolic process diphosphate metabolic process cementum mineralization regulation of stem cell proliferation positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway negative regulation of fibroblast growth factor production regulation of postsynaptic density assembly positive regulation of mitotic cell cycle DNA replication response to sodium phosphate positive regulation of vascular endothelial cell proliferation positive regulation of hepatic stellate cell activation positive regulation of parathyroid hormone secretion positive regulation of endothelial cell chemotaxis regulation of extrinsic apoptotic signaling pathway in absence of ligand MAPK cascade skeletal system development ossification endochondral ossification endochondral bone growth JAK-STAT cascade positive regulation of phospholipase activity bone mineralization chondrocyte proliferation positive regulation of tyrosine phosphorylation of STAT protein negative regulation of developmental growth cartilage development bone morphogenesis positive regulation of ERK1 and ERK2 cascade bone maturation fibroblast growth factor receptor apoptotic signaling pathway positive regulation of endothelial cell proliferation morphogenesis of an epithelium lens morphogenesis in camera-type eye cell-cell signaling negative regulation of cell proliferation regulation of collagen metabolic process oligodendrocyte development substantia nigra development central nervous system myelination cell differentiation regulation of ossification positive regulation of bone mineralization forebrain development positive regulation of protein ubiquitination somatic stem cell population maintenance post-anal tail morphogenesis p38MAPK cascade positive regulation of neuron apoptotic process negative regulation of cell differentiation regulation of osteoclast differentiation negative regulation of mitotic nuclear division negative regulation of smoothened signaling pathway regulation of bone remodeling digestive tract morphogenesis regulation of developmental growth response to axon injury negative regulation of astrocyte differentiation inner ear development negative regulation of epithelial cell proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of developmental process positive regulation of multicellular organismal process inner ear receptor cell differentiation bone development axonogenesis involved in innervation alveolar secondary septum development bone trabecula morphogenesis lens fiber cell development ERK1 and ERK2 cascade positive regulation of cell proliferation in bone marrow epithelial cell fate commitment cochlea development positive regulation of canonical Wnt signaling pathway positive regulation of gene expression regulation of extracellular matrix disassembly cell migration regulation of lipid metabolic process glucose homeostasis cholesterol homeostasis positive regulation of catalytic activity positive regulation of proteolysis phosphate ion homeostasis regulation of bile acid biosynthetic process positive regulation of DNA biosynthetic process response to ischemia female pregnancy response to nutrient levels cellular response to lipopolysaccharide cellular response to growth factor stimulus cellular response to histamine cellular response to nerve growth factor stimulus response to bile acid neuron migration protein phosphorylation chordate embryonic development regulation of cell differentiation phosphatidylinositol-mediated signaling skeletal system morphogenesis outflow tract septum morphogenesis membranous septum morphogenesis axonogenesis regulation of smoothened signaling pathway post-embryonic development embryonic pattern specification organ morphogenesis negative regulation of keratinocyte proliferation morphogenesis of embryonic epithelium pyramidal neuron development gland morphogenesis positive regulation of Wnt signaling pathway otic vesicle formation hair follicle morphogenesis response to lipopolysaccharide lacrimal gland development regulation of osteoblast proliferation organ growth fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow fibroblast growth factor receptor signaling pathway involved in hemopoiesis fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow odontogenesis cell fate commitment response to ethanol regulation of osteoblast differentiation lung alveolus development mesodermal cell differentiation embryonic digestive tract morphogenesis embryonic organ morphogenesis digestive tract development embryonic organ development reproductive structure development embryonic cranial skeleton morphogenesis epidermis morphogenesis branching morphogenesis of a nerve regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation regulation of smooth muscle cell differentiation positive regulation of cell division ventricular cardiac muscle tissue morphogenesis limb bud formation branching involved in prostate gland morphogenesis bud elongation involved in lung branching lung lobe morphogenesis positive regulation of epithelial cell proliferation involved in lung morphogenesis prostate gland morphogenesis prostate epithelial cord elongation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis squamous basal epithelial stem cell differentiation involved in prostate gland acinus development lateral sprouting from an epithelium mammary gland bud formation epithelial cell proliferation involved in salivary gland morphogenesis branch elongation involved in salivary gland morphogenesis branching involved in labyrinthine layer morphogenesis regulation of morphogenesis of a branching structure mesenchymal cell differentiation involved in lung development mesenchymal cell proliferation involved in lung development regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to hypoxia cellular response to transforming growth factor beta stimulus positive regulation of vascular smooth muscle cell proliferation cranial skeletal system development neuromuscular junction development synaptic vesicle transport coronal suture morphogenesis epithelial tube branching involved in lung morphogenesis endodermal digestive tract morphogenesis
          It has to be done as per old AB suggested Products section.

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