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Invitrogen
Phospho-Leptin Receptor (Tyr986) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-Leptin Receptor (Tyr986) Antibody (PA5-105947) in WB
Western blot analysis of Phospho-Leptin Receptor (Tyr986) extracts from COLO205 cells (heat-shock treatment). Samples were incubated with Phospho-Leptin Receptor (Tyr986) polyclonal antibody (Product # PA5-105947) using a dilution of 1:1,000. Observed bands: 96 kDa.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105947
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LEPR(Accession P48357), corresponding to amino acid residues around phosphorylated Tyr986.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of Leptin Receptor only when phosphorylated at Tyr986.
Target Information
The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen CD295; CD295 antigen; cytokine receptor; HuB219.2; OB receptor; splice variant form 12.1; Ob receptor; splice variant form 13.2; Ob receptor; splice variant form 6.4; Ob receptor; unnamed protein product
Gene Aliases: CD295; huB219; LEP-R; LEPRD; OB-R; OBR
UniProt ID: (Human) P48357
Entrez Gene ID: (Human) 3953
angiogenesis
energy reserve metabolic process
phagocytosis
cell surface receptor signaling pathway
multicellular organism development
positive regulation of cell proliferation
negative regulation of autophagy
cytokine-mediated signaling pathway
sexual reproduction
T cell differentiation
leptin-mediated signaling pathway
glucose homeostasis
response to leptin
regulation of bone remodeling
system development
regulation of transport
regulation of feeding behavior
energy homeostasis
receptor signaling pathway via STAT
bone growth
positive regulation of cold-induced thermogenesis
transport across blood-brain barrier
regulation of cytokine production involved in inflammatory response
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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