Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

Phospho-BCL6 (Ser343) Polyclonal Antibody

View all (108) BCL6 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Phospho-BCL6 (Ser343) Polyclonal Antibody

Product Details

PA5-105969

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human BCL6(Accession P41182), corresponding to amino acid residues around phosphorylated Ser343.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817368

Product Specific Information

Antibody detects endogenous levels of Bcl6 only when phosphorylated at Ser343.

Target Information

Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: B cell CLL/lymphoma 6; B-cell leukemia/lymphoma 5; B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; protein LAZ-3; transcriptional repressor; B-cell CLL/lymphoma 6 spliced short isoform; transcriptional repressor; zinc finger protein 51; unnamed protein product; zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S

View more View less

Gene Aliases: BCL5; BCL6A; LAZ3; ZBTB27; ZNF51

View more View less

UniProt ID: (Human) P41182, (Mouse) P41183

View more View less

Entrez Gene ID: (Human) 604, (Mouse) 12053

View more View less

Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding intronic transcription regulatory region sequence-specific DNA binding transcription corepressor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding chromatin DNA binding identical protein binding sequence-specific DNA binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of cytokine production regulation of germinal center formation regulation of immune system process negative regulation of B cell apoptotic process cellular response to DNA damage stimulus negative regulation of cell growth type 2 immune response regulation of cell proliferation regulation of apoptotic process positive regulation of apoptotic process regulation of T cell differentiation positive regulation of regulatory T cell differentiation regulation of cell differentiation positive regulation of cell differentiation negative regulation of transcription, DNA-templated regulation of inflammatory response regulation of immune response positive regulation of lymphocyte activation regulation of leukocyte cell-cell adhesion negative regulation of mitotic cell cycle DNA replication cell morphogenesis negative regulation of cell-matrix adhesion germinal center formation negative regulation of type 2 immune response regulation of transcription from RNA polymerase II promoter Rho protein signal transduction spermatogenesis protein localization negative regulation of cell proliferation actin cytoskeleton organization B cell differentiation positive regulation of B cell proliferation heterochromatin assembly negative regulation of mast cell cytokine production negative regulation of Rho protein signal transduction negative regulation of apoptotic process regulation of memory T cell differentiation negative regulation of cell differentiation negative regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway negative regulation of isotype switching to IgE isotypes erythrocyte development positive regulation of cell motility negative regulation of cellular senescence
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support