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Invitrogen
Phospho-SRC1 (Thr1179) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-106041
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NCOA1(Accession Q15788), corresponding to amino acid residues around phosphorylated Thr1179.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of KAT13A/SRC1 only when phosphorylated at Thr1179.
Target Information
Clone 1135 recognizes SRC-1, steroid-receptor coactivator-1. SRC-1 is a member of a gene family that functions in the full transcriptional activation of the steroid hormone receptor superfamily and contains intrinsic histone acetyltransferase activity. SRC-1 has a molecular weight of 160 kDa and has a basic helix-loop-helix (bHLH)-PAS domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ASV; c-SRC; class E basic helix-loop-helix protein 74; Hin-2; Hin-2 protein; nuclear receptor coactivator protein 1; p60-Src; renal carcinoma antigen NY-REN-52; SRC-1; SRC-1 (-Q); steroid receptor coactivator 1; steroid receptor coactivator-1; unnamed protein product
Gene Aliases: bHLHe42; bHLHe74; F-SRC-1; KAT13A; mNRC-1; NCoA-1; NRC-1; RIP160; SRC-1; SRC-a; SRC1
UniProt ID: (Human) Q15788, (Mouse) P70365
Entrez Gene ID: (Human) 8648, (Mouse) 17977
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
protein binding
ligand-dependent nuclear receptor binding
estrogen receptor binding
retinoic acid receptor binding
macromolecular complex binding
retinoid X receptor binding
protein dimerization activity
peptide-lysine-N-acetyltransferase activity
positive regulation of transcription from RNA polymerase II promoter by galactose
regulation of transcription, DNA-templated
lactation
male gonad development
response to hormone
bile acid and bile salt transport
cerebellum development
hippocampus development
hypothalamus development
cerebral cortex development
intracellular estrogen receptor signaling pathway
response to estradiol
response to retinoic acid
response to progesterone
cellular response to hormone stimulus
peroxisome proliferator activated receptor signaling pathway
mRNA transcription from RNA polymerase II promoter
positive regulation of apoptotic process
estrous cycle
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of female receptivity
positive regulation of transcription from RNA polymerase II promoter
progesterone receptor signaling pathway
male mating behavior
regulation of cellular response to insulin stimulus
positive regulation of adipose tissue development
regulation of thyroid hormone mediated signaling pathway
labyrinthine layer morphogenesis
cellular response to Thyroglobulin triiodothyronine
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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