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Invitrogen

CYLD Polyclonal Antibody

View all (16) CYLD antibodies

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CYLD Polyclonal Antibody

Product Details

PA5-106325

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CYLD(Accession Q9NQC7), corresponding to amino acid residues V876-L926.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2854002

Product Specific Information

Antibody detects endogenous levels of total CYLD.

Target Information

CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. Mutated CYLD is known to be associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 40S ribosomal protein S3a-like; cyld; cylindromatosis (turban tumor syndrome); deubiquitinating enzyme CYLD; FLJ20180; FLJ31664; FLJ78684; probable ubiquitin carboxyl-terminal hydrolase CYLD; probable ubiquitin carboxyl-terminal hydrolase CYLD-like; retinitis pigmentosa 1 homolog; ubiquitin specific peptidase like 2; ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; ubiquitin-specific-processing protease CYLD; unnamed protein product

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Gene Aliases: 2010013M14Rik; 2900009M21Rik; BRSS; C130039D01Rik; CDMT; CYLD1; CYLDI; EAC; FTDALS8; LRRGT00003; MFT; MFT1; mKIAA0849; Rp1; Rp1h; SBS; TEM; USPL2

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UniProt ID: (Human) Q9NQC7, (Rat) Q66H62, (Mouse) Q80TQ2

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Entrez Gene ID: (Human) 1540, (Rat) 312937, (Mouse) 74256

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Function(s)
thiol-dependent ubiquitin-specific protease activity protein binding zinc ion binding protein kinase binding Lys63-specific deubiquitinase activity ubiquitinyl hydrolase activity, acting on linear ubiquitin proline-rich region binding Lys48-specific deubiquitinase activity
Process(es)
regulation of mitotic cell cycle biological_process regulation of tumor necrosis factor-mediated signaling pathway protein deubiquitination negative regulation of I-kappaB kinase/NF-kappaB signaling CD4-positive or CD8-positive, alpha-beta T cell lineage commitment innate immune response regulation of B cell differentiation positive regulation of T cell differentiation negative regulation of JNK cascade homeostasis of number of cells regulation of inflammatory response negative regulation of inflammatory response positive regulation of T cell receptor signaling pathway regulation of necroptotic process necroptotic process regulation of microtubule cytoskeleton organization protein K63-linked deubiquitination negative regulation of canonical Wnt signaling pathway regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation protein catabolic process at postsynapse ripoptosome assembly involved in necroptotic process negative regulation of NIK/NF-kappaB signaling regulation of cilium assembly negative regulation of p38MAPK cascade positive regulation of cellular protein localization protein linear deubiquitination negative regulation of interleukin-18-mediated signaling pathway positive regulation of extrinsic apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway I-kappaB kinase/NF-kappaB signaling defense response to bacterium positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of T cell receptor signaling pathway negative regulation of type I interferon production nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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