Search
Invitrogen
GRK5 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 4
GRK5 Antibody (PA5-106484) in IHC (P)
Immunohistochemistry analysis of GRK5 in human pancreatic cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with GRK5 polyclonal antibody (Product # PA5-106484) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-106484
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GRK5(Accession P34947), corresponding to amino acid residues Y362-F412.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total GRK5.
Target Information
GRK5 is a serine/threonine kinase that regulates the activity of a variety of G protein-coupled receptors and the motility of polymorphonuclear leukocytes. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-CP4; g protein-coupled receptor kinase GRK5; GRK; GRK-pan; Pan-GRK; unnamed protein product
Gene Aliases: 1200003L19Rik; AlphaCP-4; FP2025; GPRK5
UniProt ID: (Human) P34947, (Rat) Q62833, (Mouse) Q8VEB1, (Mouse) P57724
Entrez Gene ID: (Human) 2869, (Rat) 59075, (Mouse) 14773, (Mouse) 59092
desensitization of G-protein coupled receptor protein signaling pathway
signal transduction
tachykinin receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of cell proliferation
regulation of signal transduction
response to cocaine
negative regulation of apoptotic process
fat cell differentiation
oligodendrocyte differentiation
regulation of cell cycle
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of transcription from RNA polymerase II promoter
regulation of gene expression
regulation of mRNA stability
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of mRNA splicing, via spliceosome
regulation of mRNA metabolic process
protein autophosphorylation
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support