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Invitrogen

TRIF Polyclonal Antibody

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TRIF Polyclonal Antibody

Product Details

PA5-106871

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TICAM1(Accession Q8IUC6), corresponding to amino acid residues R403-I453.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2854535

Product Specific Information

Antibody detects endogenous levels of total TICAM1.

Target Information

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: hCG_39321; HSD34; proline-rich, vinculin and TIR domain-containing protein B; putative NF-kappa-B-activating protein 502H; RNF36; TI; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor inducing interferon-beta; toll like receptor adaptor molecule 1; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1; unnamed protein product

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Gene Aliases: IIAE6; MyD88-3; PRVTIRB; TICAM-1; TRIF

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UniProt ID: (Human) Q8IUC6, (Mouse) Q80UF7

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Entrez Gene ID: (Human) 148022, (Mouse) 106759, (Rat) 363328

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Function(s)
protein binding protein kinase binding signaling adaptor activity binding, bridging
Process(es)
toll-like receptor signaling pathway macrophage activation involved in immune response positive regulation of myeloid dendritic cell cytokine production MyD88-independent toll-like receptor signaling pathway signal transduction cell surface receptor signaling pathway positive regulation of autophagy positive regulation of gene expression positive regulation of B cell proliferation positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production response to lipopolysaccharide positive regulation of chemokine production positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell activation toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly response to exogenous dsRNA innate immune response positive regulation of nitric oxide biosynthetic process positive regulation of B cell activation defense response to virus cellular response to lipopolysaccharide apoptotic signaling pathway cellular response to oxidised low-density lipoprotein particle stimulus positive regulation of cytokine production involved in inflammatory response TRIF-dependent toll-like receptor 4 signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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