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Invitrogen
ACP5 Polyclonal Antibody
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FIGURE: 1 / 2
ACP5 Antibody (PA5-106914) in IHC (P)
Immunohistochemistry analysis of ACP5 in human ovarian cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ACP5 polyclonal antibody (Product # PA5-106914) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-106914
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ACP5(Accession P13686), corresponding to amino acid residues A12-G62.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ACP5.
Target Information
Tartrate-resistant acid phosphatase (TRAP) is a basic iron-binding protein with high activity towards phosphoproteins, ATP and 4-nitrophenyl phosphatase. It is detected in human alveolar macrophages, osteoclasts, spleen and liver. Its expression is increased in spleen and monocytes of patients with Gaucher's disease; spleenocytes and circulating leukocytes of patients with hairy cell leukemia; spleen of patients with Hodgkin's lymphoma and in the sera of patients undergoing active bone turnover.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acid phosphatase type V; ACP5; human purple acid phosphatase; tartrate-resistant acid ATPase; tartrate-resistant acid phosphatase 5a; tartrate-resistant acid phosphatase 5b; TR-AP; TRAPase; trATPase; type 5 acid phosphatase; unnamed protein product
Gene Aliases: HPAP; TRACP; TRACP5a; TRACP5b; TRAP; TrATPase; TTRRAP
UniProt ID: (Human) P13686, (Mouse) Q05117, (Rat) P29288
Entrez Gene ID: (Human) 54, (Mouse) 11433, (Rat) 25732
negative regulation of cell adhesion
dephosphorylation
positive regulation of cell migration
response to lipopolysaccharide
negative regulation of interleukin-1 beta production
negative regulation of interleukin-12 production
negative regulation of tumor necrosis factor production
negative regulation of superoxide anion generation
response to cytokine
negative regulation of nitric oxide biosynthetic process
bone resorption
negative regulation of inflammatory response
defense response to Gram-positive bacterium
bone morphogenesis
ossification
response to mechanical stimulus
response to zinc ion
osteoclast differentiation
response to insulin
multicellular organismal response to stress
response to L-ascorbic acid
cellular response to zinc ion starvation
response to macrophage colony-stimulating factor
response to ethanol
response to cholesterol
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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