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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
The Slc37 gene family consists of four members which have 10-12 predicted transmembrane domains and belong to the sugar-phosphate transporter superfamily. Recent experiments have demonstrated that Slc37A2 is a macrophage-specific gene selectively expressed in obese white adipose tissue. Its transcript is also expressed in spleen and thymus and the cell lines RAW264.7 and THP-1. Compared to wild-type mice, Slc37A2 mRNA is expressed at nine-fold higher levels in abdominal epididymal fat deposits of ob/ob mice, suggesting that it may be required to limit the contribution of macrophages to the inflammatory state present in obesity. Slc37A2 protein is post-translationally modified with the addition of N-linked glycans and migrates as a heterogeneous species of 50-75 kDa.
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Protein Aliases: cAMP inducible 2 protein; cAMP inducible gene 2; cAMP-inducible protein 2; solute carrier family 37 (glucose-6-phosphate transporter), member 2; solute carrier family 37 (glycerol-3-phosphate transporter), member 1; solute carrier family 37 (glycerol-3-phosphate transporter), member 2; solute carrier family 37 member 2; sugar phosphate exchanger 2; sugar-phosphate exchange protein 2; unnamed protein product
Gene Aliases: cI-2; ci2; G3PP; pp11662; Slc37a1; SPX2
UniProt ID: (Human) Q8TED4, (Mouse) Q9WU81
Entrez Gene ID: (Human) 219855, (Mouse) 56857
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