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Invitrogen
MTR Polyclonal Antibody
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FIGURE: 1 / 7
MTR Antibody (PA5-114366) in IHC (P)
Immunohistochemistry analysis of MTR in paraffin-embedded human pancreatic cancer tissues. Antigen retrieval was performed with citrate buffer (pH6, 20 min). Samples were blocked with 10% goat serum and incubated in MTR polyclonal antibody (Product # PA5-114366) at a dilution of 1 µg/mL (overnight, 4°C), followed by biotinylated goat anti-rabbit IgG (30 min, 37°C) and Strepavidin-Biotin-Complex (SABC) with ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-114366
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human MTR recombinant protein (Position: V880-D1095).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human placenta tissue, human K562 whole cell. IHC: human placenta tissue, mouse brain tissue, rat brain tissue, rat brain tissue, human pancreatic cancer tissue. Flow: SiHa cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
MTR encodes the enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-methyltetrahydrofolate-homocysteine methyltransferase 1; cobalamin-dependent methionine synthase; FLJ33168; FLJ43216; FLJ45386; MS; similar to Escherichia coli methionine synthase encoded by GenBank Accession Number J04975; unnamed protein product; vitamin-B12 dependent methionine synthase
Gene Aliases: cblG; D830038K18Rik; HMAG; methioninesynthase; MS
UniProt ID: (Human) Q99707, (Mouse) A6H5Y3, (Rat) Q9Z2Q4
Entrez Gene ID: (Human) 4548, (Mouse) 238505, (Rat) 81522
sulfur amino acid metabolic process
nervous system development
cobalamin metabolic process
axon regeneration
methylation
pteridine-containing compound metabolic process
tetrahydrofolate metabolic process
response to axon injury
homocysteine metabolic process
L-methionine biosynthetic process
L-methionine salvage
cellular response to nitric oxide
protein methylation
methionine metabolic process
cellular response to methionine
response to alcohol
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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