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Invitrogen
FRZB Polyclonal Antibody
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FIGURE: 1 / 1
FRZB Antibody (PA5-114374) in WB
Western blot analysis of FRZB in the following samples: Lane 1: rat brain tissue lysates, Lane 2: rat kidney tissue lysates, Lane 3: rat heart tissue lysates, Lane 4: mouse brain tissue lysates, Lane 5: mouse kidney tissue lysates, Lane 6: mouse heart tissue lysates. Samples consisting of 50 µg (reducing conditions) of protein was separated with 5-20% SDS-PAGE gel (70V, Stacking gel; 90V, Resolving gel; 2-3 hrs.), transferred to a Nitrocellulose membrane (150mA, 50-90 min) and washed with TBS-0.1% Tween (3 times, 5 minutes/wash) and blocke... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-114374
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived mouse FRZB recombinant protein (Position: N49-K311).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat brain tissue, rat kidney tissue, rat heart tissue, mouse brain tissue, mouse kidney tissue, mouse heart tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FREOS1; frezzled; frizzled homolog-related; frizzled-related protein 1; FRZB1sFRP-3; secreted frizzled-related sequence protein 3; sFRP-3; SFRP3frezzled; unnamed protein product
Gene Aliases: FRE; frezzled; FRITZ; Frp; FRP-3; FRZB-1; FRZB-PEN; FRZB1; FZRB; hFIZ; OS1; SFRP3; SRFP3
UniProt ID: (Human) Q92765, (Mouse) P97401
Entrez Gene ID: (Human) 2487, (Mouse) 20378, (Rat) 295691
negative regulation of cell proliferation
negative regulation of cell development
neural crest cell differentiation
negative regulation of Wnt signaling pathway
negative regulation of cell growth
non-canonical Wnt signaling pathway
inner ear morphogenesis
positive regulation of apoptotic process
regulation of cell differentiation
positive regulation of fat cell differentiation
convergent extension involved in organogenesis
canonical Wnt signaling pathway
negative regulation of cartilage development
somite development
negative regulation of hepatocyte differentiation
negative regulation of canonical Wnt signaling pathway
cochlea morphogenesis
skeletal system development
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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