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Invitrogen
Phospho-DNMT1 (Tyr399) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-114569
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human Dnmt1 around the phosphorylation site of Tyr399.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of Dnmt1 only when phosphorylated at Tyr399.
Target Information
This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CXXC-type zinc finger protein 9; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; DNMT1; FLJ16293; MGC104992; unnamed protein product
Gene Aliases: ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI; MCMT
UniProt ID: (Human) P26358
Entrez Gene ID: (Human) 1786
DNA binding
chromatin binding
RNA binding
DNA (cytosine-5-)-methyltransferase activity
protein binding
methyltransferase activity
zinc ion binding
methyl-CpG binding
DNA-methyltransferase activity
lncRNA binding
histone H3K18ub reader activity
histone H3K23ub reader activity
histone H3K14ub reader activity
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
methylation-dependent chromatin silencing
positive regulation of gene expression
negative regulation of gene expression
hypermethylation of CpG island
chromosomal DNA methylation maintenance following DNA replication
negative regulation of phenotypic switching
positive regulation of vascular smooth muscle cell proliferation
negative regulation of vascular smooth muscle cell differentiation
negative regulation of vascular associated smooth muscle cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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