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Invitrogen

Phospho-HSP90 (Tyr627) Polyclonal Antibody

View all (46) HSP90 antibodies

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Phospho-HSP90 (Tyr627) Polyclonal Antibody

Product Details

PA5-114584

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human Hsp90 alpha around the phosphorylation site of Tyr627.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899220

Product Specific Information

Antibody detects endogenous levels of Hsp90 alpha only when phosphorylated at Tyr627.

Target Information

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 and mitochondria (Chen et al., 2005 ).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 84 kD heat shock protein; 90kDa heat shock protein; ATHS83; AtHsp90-1; ATHSP90.1; epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; F6N7.13; F6N7_13; heat shock 84 kDa; heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein 1, beta; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 1, beta; HEAT SHOCK PROTEIN 81-1; HEAT SHOCK PROTEIN 83; heat shock protein 86; heat shock protein 90 alpha (cytosolic), class B member 1; heat shock protein 90 kDa; heat shock protein 90, alpha (cytosolic), class A member 1; HEAT SHOCK PROTEIN 90-1; heat shock protein 90.1; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein 90kDa alpha family class B member 1; heat shock protein family C member 1; heat shock protein family C member 3; heat shock protein, 1; heat shock protein, 84 kDa 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; heat-shock protein hsp84; heat-shock protein hsp86; HSP; HSP 84; HSP 86; HSP81-1; HSP81.1; HSP83; HSP84; HSP86; HSP90-beta; lipopolysaccharide-associated protein 2; LPS-associated protein 2; renal carcinoma antigen NY-REN-38; retinal degeneration slow protein; TSTA; tumor-specific transplantation 84 kDa antigen; tumor-specific transplantation 86 kDa antigen; unnamed protein product

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Gene Aliases: 86kDa; 89kDa; 90kDa; D6S182; EL52; HEL-S-65p; Hsp103; hsp4; HSP84; Hsp84-1; HSP86; Hsp86-1; Hsp89; HSP89A; Hsp90; HSP90-BETA; HSP90A; HSP90B; HSP90N; HSPC1; HSPC2; HSPCA; HSPCAL1; HSPCAL4; HSPCB; HSPN; LAP-2; LAP2

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UniProt ID: (Human) P07900, (Human) P08238, (Mouse) P07901, (Rat) P82995, (Mouse) P11499, (Rat) P34058

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Entrez Gene ID: (Human) 3320, (Human) 3326, (Mouse) 15519, (Rat) 299331, (Mouse) 15516, (Rat) 301252

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Function(s)
UTP binding CTP binding RNA binding mRNA binding protein binding ATP binding GTP binding ATPase activity sulfonylurea receptor binding protein phosphatase binding MHC class II protein complex binding nitric-oxide synthase regulator activity TPR domain binding ubiquitin protein ligase binding dATP binding AP-3 adaptor complex binding identical protein binding protein homodimerization activity histone deacetylase binding protein binding involved in protein folding ion channel binding tau protein binding GTPase binding Rho GDP-dissociation inhibitor binding DNA polymerase binding scaffold protein binding disordered domain specific binding ATP-dependent protein folding chaperone enzyme-substrate adaptor activity protein tyrosine kinase binding double-stranded RNA binding protein kinase regulator activity kinase binding protein kinase binding heat shock protein binding peptide binding ATP-dependent protein binding cadherin binding protein dimerization activity protein phosphatase activator activity receptor ligand inhibitor activity histone methyltransferase binding protein carrier chaperone heterocyclic compound binding
Process(es)
placenta development protein folding virion attachment to host cell positive regulation of transforming growth factor beta receptor signaling pathway regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein localization cellular response to heat positive regulation of protein import into nucleus negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation positive regulation of cell size protein stabilization chaperone-mediated protein complex assembly regulation of cell cycle cellular response to interleukin-4 positive regulation of protein serine/threonine kinase activity fibril organization negative regulation of proteasomal protein catabolic process negative regulation of complement-dependent cytotoxicity telomerase holoenzyme complex assembly positive regulation of protein localization to cell surface response to unfolded protein telomere maintenance via telomerase neuron migration response to dietary excess activation of innate immune response positive regulation of defense response to virus by host skeletal muscle contraction nitric oxide biosynthetic process response to heat response to cold response to xenobiotic stimulus response to salt stress positive regulation of lamellipodium assembly cardiac muscle cell apoptotic process negative regulation of striated muscle cell apoptotic process protein import into mitochondrial matrix positive regulation of protein polymerization response to follicle-stimulating hormone positive regulation of interferon-beta production response to isolation stress cellular response to platelet-derived growth factor stimulus protein refolding response to cocaine regulation of apoptotic process response to estrogen positive regulation of cytotoxic T cell differentiation positive regulation of protein catabolic process response to antibiotic protein maturation positive regulation of cardiac muscle contraction response to caloric restriction cellular response to hydrogen peroxide cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to hypoxia cellular response to virus regulation of postsynaptic membrane neurotransmitter receptor levels neurofibrillary tangle assembly regulation of protein complex stability chaperone-mediated autophagy mitochondrial transport positive regulation of telomere maintenance via telomerase regulation of protein complex assembly protein unfolding nitric oxide metabolic process
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