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Invitrogen

Actin Polyclonal Antibody

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Actin Polyclonal Antibody

Product Details

PA5-114817

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ACTC1(Accession P68032), corresponding to amino acid residues M1-F33.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899453

Product Specific Information

Antibody detects endogenous levels of total Actin-alpha/gamma.

Target Information

Actin exists as a ubiquitous protein involved with filament formation that make up large portions of the cytoskeleton. Actin filaments interact with myosin to assist in muscle contraction as well as aiding in cell motility and cytokinesis. In vertebrates there are three groups of actin isoforms: alpha, beta and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exists in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ACT2; ACTA1; ACTA2; ACTC; ACTG2; actin 2; actin 7; actin alpha 1; Actin is a protein with a high degree of evolutionary conservation that undergoes polymerization to generate filaments, which subsequently assemble into interconnected networks within the cytoplasm of cells.; actin, alpha 2, smooth muscle, aorta; actin, alpha, cardiac 1; actin, gamma 2, smooth muscle, enteric; actin, gamma, cytoplasmic 1; actin-like protein; alpha-actin; alpha-actin cardiac; alpha-actin-1; alpha-actin-2; alpha-actin-3; alpha-cardiac actin; alpha-sma; alpha-smooth muscle actin; AtACT7; Atcb; beta cytoskeletal actin; beta-actin; cell growth-inhibiting gene 46 protein; cytoplasmic beta-actin; cytoplasmic protein; cytoskeletal gamma-actin; DEFORMED ROOT HAIRS 1; DER1; ENHANCER OF LRX1 2; ENL2; epididymis luminal protein 176; FIZ2; FRIZZY AND KINKED SHOOTS 2; gamma-2-actin; gamma-actin; gamma-enteric smooth muscle actin; GIG46; I(2)-actin; LIGHT STRESS-REGULATED 2; LSR2; MYH9.2; MYH9_2; nemaline myopathy type 3; pan actin; PS1TP5-binding protein 1; RP5-1068B5.2; smooth muscle alpha-actin; smooth muscle gamma-actin; unnamed protein product

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Gene Aliases: ACT; ACTA; ACTA3; ACTC; ACTE; ACTG; ACTGE; ACTL3; ACTSA; ACTSG; Actx; ASD5; ASMA; BKRNS; BNS; BRWS1; CFTD; CFTD1; CFTDM; CMD1R; CMH11; CMYO2A; CMYO2B; CMYO2C; CMYP2A; CMYP2B; CMYP2C; CSMH; DDS1; DFNA20; DFNA26; HEL-176; LVNC4; MMIHS5; MPFD; NEM1; NEM2; NEM3; PS1TP5BP1; SHPM; SMDYS; SMGA; THC8; VSCM; VSCM1

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UniProt ID: (Human) P68133, (Human) P62736, (Human) P60709, (Human) P68032, (Human) P63261, (Human) P63267, (Rat) P68136, (Rat) P62738, (Rat) P60711, (Rat) P68035, (Rat) P63259, (Rat) P63269

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Entrez Gene ID: (Human) 58, (Human) 59, (Human) 60, (Human) 70, (Human) 71, (Human) 72, (Rat) 29437, (Rat) 81633, (Rat) 81822, (Rat) 29275, (Rat) 287876, (Rat) 25365

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Function(s)
structural constituent of cytoskeleton protein binding ATP binding ATPase activity myosin binding ADP binding protein kinase binding kinesin binding nitric-oxide synthase regulator activity Tat protein binding nucleosomal DNA binding identical protein binding tau protein binding nitric-oxide synthase binding structural constituent of postsynaptic actin cytoskeleton transporter regulator activity microfilament motor activity profilin binding ubiquitin protein ligase binding
Process(es)
actin filament organization positive regulation of gene expression actin filament-based movement skeletal muscle thin filament assembly actomyosin structure organization actin-myosin filament sliding cardiac myofibril assembly cardiac muscle tissue morphogenesis heart contraction mesenchyme migration response to xenobiotic stimulus negative regulation of apoptotic process response to ethanol cardiac muscle contraction cytoplasmic actin-based contraction involved in cell motility angiogenesis morphogenesis of a polarized epithelium axonogenesis response to mechanical stimulus positive regulation of cell migration sarcomere organization cell motility regulation of stress fiber assembly response to calcium ion regulation of focal adhesion assembly cellular response to interferon-gamma positive regulation of wound healing postsynaptic actin cytoskeleton organization tight junction assembly regulation of transepithelial transport regulation of synaptic vesicle endocytosis protein localization to bicellular tight junction muscle contraction cytoskeleton organization regulation of blood pressure response to virus vascular smooth muscle contraction positive regulation of hepatic stellate cell migration positive regulation of hepatic stellate cell contraction positive regulation of ERK1 and ERK2 cascade cellular response to transforming growth factor beta stimulus juxtaglomerular apparatus development glomerular mesangial cell development positive regulation of hepatic stellate cell activation establishment or maintenance of cell polarity circadian rhythm dynein-driven meiotic oscillatory nuclear movement adherens junction assembly response to immobilization stress apical protein localization regulation of norepinephrine uptake regulation of cell cycle retina development in camera-type eye cellular response to electrical stimulus protein localization to adherens junction cellular response to cytochalasin B regulation of protein localization to plasma membrane positive regulation of double-strand break repair via homologous recombination cellular response to potassium ion skeletal muscle fiber adaptation response to steroid hormone skeletal muscle fiber development maintenance of blood-brain barrier platelet aggregation cellular response to interleukin-6 cellular response to acetaldehyde chromatin remodeling regulation of transcription from RNA polymerase II promoter microtubule nucleation positive regulation of cell proliferation substantia nigra development regulation of mitotic metaphase/anaphase transition regulation of apoptotic process positive regulation of T cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation positive regulation of myoblast differentiation positive regulation of transcription, DNA-templated positive regulation of norepinephrine uptake regulation of G0 to G1 transition positive regulation of stem cell population maintenance regulation of G1/S transition of mitotic cell cycle regulation of double-strand break repair positive regulation of double-strand break repair regulation of nucleotide-excision repair
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