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Invitrogen

ARF1/ARF3/ARF5/ARF6 Polyclonal Antibody

View all (3) ARF Pan antibodies

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ARF1/ARF3/ARF5/ARF6 Polyclonal Antibody

Product Details

PA5-114874

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ARF3(Accession P61204), corresponding to amino acid residues H146-K181.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899510

Product Specific Information

Antibody detects endogenous levels of total ARF3.

Target Information

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ADP ribosylation factor 1; ADP ribosylation factor 3; ADP ribosylation factor 4; ADP ribosylation factor 5; ADP ribosylation factor 6; ADP-ribosylation factor (ARF1); ADP-ribosylation factor 2; ARF; ARF6; liver regeneration-related protein LRRG202; pan ARF; small GTP binding protein; unnamed protein product

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Gene Aliases: Ac1-253; ARF2; PVNH8

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UniProt ID: (Human) P84077, (Human) P61204, (Human) P18085, (Human) P84085, (Human) P62330, (Rat) P84079, (Rat) P84082, (Rat) P61206, (Rat) P61751, (Rat) P84083, (Rat) P62332

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Entrez Gene ID: (Human) 375, (Human) 377, (Human) 378, (Human) 381, (Human) 382, (Rat) 64310, (Rat) 79119, (Rat) 140940, (Rat) 79120, (Rat) 79117, (Rat) 79121

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Function(s)
magnesium ion binding RNA binding GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding protein domain specific binding guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding NAD+-protein-arginine ADP-ribosyltransferase activity phospholipase D activator activity GDP binding protein binding, bridging thioesterase binding
Process(es)
regulation of receptor internalization cellular copper ion homeostasis intracellular protein transport vesicle-mediated transport regulation of Arp2/3 complex-mediated actin nucleation glycolipid transport long term synaptic depression dendritic spine organization cellular response to virus protein localization to Golgi membrane mitotic cleavage furrow ingression retrograde vesicle-mediated transport, Golgi to ER ER to Golgi vesicle-mediated transport epidermal growth factor receptor signaling pathway cell migration negative regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter response to axon injury regulation of synapse organization cilium morphogenesis dendritic spine development regulation of postsynapse organization regulation of cilium assembly regulation of reactive oxygen species metabolic process learning apical protein localization establishment or maintenance of epithelial cell apical/basal polarity protein localization to cilium cell adhesion regulation of neuron projection development positive regulation of neuron projection development positive regulation of actin filament polymerization cortical actin cytoskeleton organization endocytic recycling protein localization to cell surface regulation of Rac protein signal transduction protein localization to endosome negative regulation of receptor-mediated endocytosis synaptic vesicle endocytosis positive regulation of protein secretion regulation of filopodium assembly positive regulation of keratinocyte migration regulation of dendritic spine development protein localization to plasma membrane ruffle assembly maintenance of postsynaptic density structure positive regulation of focal adhesion disassembly positive regulation of protein localization to plasma membrane positive regulation of mitotic cytokinetic process protein localization to cleavage furrow regulation of presynapse assembly cellular response to nerve growth factor stimulus negative regulation of protein localization to cell surface negative regulation of dendrite development positive regulation of TOR signaling lysosomal membrane organization liver development actin cytoskeleton organization myeloid cell apoptotic process establishment of epithelial cell polarity hepatocyte apoptotic process Golgi to plasma membrane transport actin filament organization very-low-density lipoprotein particle assembly positive regulation of endocytosis positive regulation of calcium ion-dependent exocytosis positive regulation of dendritic spine development synaptic vesicle budding postsynaptic actin cytoskeleton organization positive regulation of sodium ion transmembrane transport positive regulation of late endosome to lysosome transport positive regulation of ER to Golgi vesicle-mediated transport regulation of phospholipid metabolic process
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