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Invitrogen

CGRP Polyclonal Antibody

View all (31) CGRP antibodies

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CGRP Polyclonal Antibody

Product Details

PA5-114931

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CALCA(Accession P06881), corresponding to amino acid residues G96-G120.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899567

Product Specific Information

Antibody detects endogenous levels of total Calcitonin.

Target Information

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha-CGRP; alpha-type calcitonin gene-related peptide; alpha-type CGRP; calcitonin; calcitonin 1; calcitonin gene related protein; calcitonin gene-related peptide I; calcitonin precursor; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; katacalcin; MGC126648; neuropeptide; alpha-CGRP; procalcitonin; RAT calcitonin; unnamed protein product

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Gene Aliases: CA; Cal1; CAL6; Calc; CALC1; calcitonin; CGRP; CGRP-1; CGRP-alpha; CGRP-I; CGRP1; CT; Ctn; KC; PCT; RATCAL6

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UniProt ID: (Human) P01258, (Mouse) P70160, (Rat) P01256

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Entrez Gene ID: (Human) 796, (Mouse) 12310, (Rat) 24241

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Function(s)
receptor binding hormone activity protein binding calcitonin receptor binding identical protein binding macromolecular complex binding receptor agonist activity neuropeptide hormone activity
Process(es)
endothelial cell proliferation vasculature development neurological system process involved in regulation of systemic arterial blood pressure vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure regulation of heart rate G-protein coupled receptor internalization monocyte chemotaxis protein phosphorylation cellular calcium ion homeostasis inflammatory response leukocyte cell-cell adhesion adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway embryo implantation feeding behavior response to heat negative regulation of calcium ion transport into cytosol negative regulation of ossification receptor internalization negative regulation of neurological system process activation of protein kinase activity positive regulation of interleukin-1 alpha production positive regulation of interleukin-8 production vasodilation endothelial cell migration positive regulation of macrophage differentiation negative regulation of osteoclast differentiation negative regulation of blood pressure positive regulation of ossification negative regulation of bone resorption negative regulation of transcription, DNA-templated negative regulation of smooth muscle contraction sperm capacitation response to pain detection of temperature stimulus involved in sensory perception of pain regulation of cytosolic calcium ion concentration calcitonin family receptor signaling pathway amylin receptor 1 signaling pathway amylin receptor 2 signaling pathway cellular response to nerve growth factor stimulus calcitonin gene-related peptide receptor signaling pathway innate immune response antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to tumor necrosis factor response to yeast cell-cell signaling regulation of blood pressure antibacterial humoral response antifungal humoral response defense response to Gram-negative bacterium defense response to Gram-positive bacterium
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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