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Invitrogen

PMCA ATPase Polyclonal Antibody

View all (4) PMCA ATPase antibodies

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PMCA ATPase Polyclonal Antibody

Product Details

PA5-114932

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ATP2B4(Accession P23634), corresponding to amino acid residues K302-L352.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899568

Product Specific Information

Antibody detects endogenous levels of total Calcium Pump PMCA4 ATPase.

Target Information

The calcium pump of the plasma membrane (PMCA ATPase) pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the sarcoplasmic and endoplasmic reticulum calcium (SERCA) ATPase and the sodium/potassium pump. Studies indicate that there are four known isoforms of the PMCA ATPase which are encoded by a multigene family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATPase, Ca++ transporting, plasma membrane 1; ATPase, Ca++ transporting, plasma membrane 2; ATPase, Ca++ transporting, plasma membrane 3; ATPase, Ca++ transporting, plasma membrane 4; Ca++ efflux pump; calcium ion efflux pump; calcium pump; cilia and flagella associated protein 39; deaf waddler; matrix-remodeling-associated protein 1; plasma membrane Ca(2+)-ATPase; plasma membrane Ca++-ATPase; plasma membrane Ca2+ pump 2; plasma membrane Ca2+-ATPases 4; plasma membrane calcium ATPase; plasma membrane calcium pump; plasma membrane calcium-ATPase isoform 1 alternative splice variant k at splice site B and splice variant b at splice site C; plasma membrane calcium-ATPase isoform 2 alternative splice variant a at splice site C; plasma membrane calcium-ATPase isoform 2, splice variant i; plasma membrane calcium-ATPase isoform 3, splice variant a at alternative splice site C; plasma membrane calcium-ATPase isoform 4 alternative splice variant x at splice site A; plasma membrane calcium-ATPase isoform 4, splice variant b at alternative splice site C; PMCA1; PMCA1kb; sarcolemmal calcium pump; unnamed protein product; wriggle

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Gene Aliases: 2810442I22Rik; 6430519O13Rik; ATP2B2; CFAP39; CLA2; D6Abb2e; DFNA82; dfw; E130111D10Rik; Gena300; jog; MRD66; MXRA1; OPCA; PMCA1; Pmca1a; Pmca1b; Pmca1c; PMCA1kb; PMCA2; PMCA2a; PMCA2i; PMCA3; PMCA3a; PMCA4; PMCA4b; PMCA4x; SCAX1; Tmy; wms; wri

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UniProt ID: (Human) P20020, (Human) Q01814, (Human) Q16720, (Human) P23634, (Mouse) G5E829, (Rat) P11505, (Mouse) Q9R0K7, (Rat) P11506, (Rat) Q64568, (Mouse) Q6Q477, (Rat) Q64542

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Entrez Gene ID: (Human) 490, (Human) 491, (Human) 492, (Human) 493, (Mouse) 67972, (Rat) 29598, (Mouse) 11941, (Rat) 24215, (Mouse) 320707, (Rat) 29599, (Mouse) 381290, (Rat) 29600

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Function(s)
nucleotide binding calcium-transporting ATPase activity protein binding ATP binding calcium ion transmembrane transporter activity ATPase activity molecular function inhibitor activity calcium ion binding calmodulin binding PDZ domain binding calcium-dependent ATPase activity P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration sodium channel regulator activity protein kinase binding protein phosphatase 2B binding nitric-oxide synthase inhibitor activity nitric-oxide synthase binding scaffold protein binding glutamate receptor binding
Process(es)
cell morphogenesis calcium ion transport cellular calcium ion homeostasis sensory organ development lactation sensory perception of sound locomotory behavior regulation of cell size cerebellum development cerebellar Purkinje cell layer morphogenesis cerebellar Purkinje cell differentiation cerebellar granule cell differentiation neuron differentiation locomotion serotonin metabolic process inner ear morphogenesis otolith mineralization cGMP metabolic process regulation of synaptic plasticity inner ear development synapse organization neuromuscular process controlling balance detection of mechanical stimulus involved in sensory perception of sound regulation of cytosolic calcium ion concentration positive regulation of calcium ion transport auditory receptor cell stereocilium organization inner ear receptor cell differentiation calcium ion transmembrane transport cochlea development regulation of postsynaptic cytosolic calcium ion concentration neural retina development regulation of transcription from RNA polymerase II promoter spermatogenesis negative regulation of gene expression urinary bladder smooth muscle contraction negative regulation of angiogenesis hippocampus development sperm motility ion transmembrane transport nitric oxide-cGMP-mediated signaling pathway negative regulation of blood vessel endothelial cell migration negative regulation of nitric oxide biosynthetic process response to hydrostatic pressure negative regulation of calcineurin-NFAT signaling cascade cellular response to epinephrine stimulus negative regulation of adrenergic receptor signaling pathway calcium ion transmembrane import into cytosol calcium ion import across plasma membrane negative regulation of the force of heart contraction transport across blood-brain barrier negative regulation of arginine catabolic process calcium ion export regulation of sodium ion transmembrane transport negative regulation of cellular response to vascular endothelial growth factor stimulus regulation of cell cycle G1/S phase transition positive regulation of protein localization to plasma membrane negative regulation of cardiac muscle hypertrophy in response to stress negative regulation of citrulline biosynthetic process regulation of cardiac conduction cellular response to acetylcholine negative regulation of cytokine production regulation of vascular smooth muscle contraction regulation of blood pressure positive regulation of bone mineralization negative regulation of cytosolic calcium ion concentration regulation of cellular response to insulin stimulus calcium ion export from cell regulation of presynaptic cytosolic calcium ion concentration cellular response to vitamin D cellular response to corticosterone stimulus
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