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Invitrogen

Cofilin 1/2 Polyclonal Antibody

View all (3) Cofilin 1/2 antibodies

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Cofilin 1/2 Polyclonal Antibody

Product Details

PA5-115034

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CFL1(Accession P23528), corresponding to amino acid residues K114-K164.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899670

Product Specific Information

Antibody detects endogenous levels of total Cofilin.

Target Information

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 18 kDa phosphoprotein; CFL-1; COF1; COF2; CofI; cofilin 1 (non-muscle); cofilin 1, non-muscle; cofilin 2 (muscle); cofilin 2, muscle; Cofilin1; epididymis secretory protein Li 15; n-cofilin; nemaline myopathy type 7; p18; unnamed protein product

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Gene Aliases: CFL; Cof; cofilin; HEL-S-15; NEM7

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UniProt ID: (Human) P23528, (Human) Q9Y281, (Rat) P45592, (Mouse) P18760, (Mouse) P45591

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Entrez Gene ID: (Human) 1072, (Human) 1073, (Rat) 29271, (Mouse) 12631, (Mouse) 12632, (Rat) 366624

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Function(s)
actin binding obsolete actin filament severing activity receptor binding protein binding protein phosphatase binding actin filament binding phosphatidylinositol bisphosphate binding
Process(es)
actin filament organization skeletal muscle tissue development actin filament depolymerization actin filament fragmentation positive regulation of actin filament depolymerization sarcomere organization muscle cell cellular homeostasis actin filament severing actin polymerization or depolymerization mitotic cytokinesis protein import into nucleus negative regulation of cell adhesion Rho protein signal transduction response to virus positive regulation of lamellipodium assembly negative regulation of lamellipodium assembly response to activity hippocampus development actin cytoskeleton organization positive regulation of cell growth negative regulation of actin filament depolymerization positive regulation of synaptic plasticity negative regulation of actin filament bundle assembly positive regulation of embryonic development negative regulation of apoptotic process positive regulation by host of viral process positive regulation of proteolysis modulation of synaptic transmission establishment of spindle localization negative regulation of unidimensional cell growth positive regulation of focal adhesion assembly positive regulation of dendritic spine development regulation of dendritic spine morphogenesis cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to ether cellular response to epidermal growth factor stimulus modification of postsynaptic actin cytoskeleton negative regulation of dendritic spine maintenance positive regulation of protein localization to cell leading edge negative regulation of postsynaptic density organization cellular response to insulin-like growth factor stimulus negative regulation of cell motility positive regulation of cell motility positive regulation of establishment of cell polarity regulating cell shape positive regulation of barbed-end actin filament capping neural crest cell migration neural fold formation protein phosphorylation establishment of cell polarity cell projection organization response to amino acid negative regulation of cell size cell motility regulation of N-methyl-D-aspartate selective glutamate receptor activity cytoskeleton organization regulation of cell morphogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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