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Invitrogen
DHRS4 Polyclonal Antibody
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FIGURE: 1 / 3
DHRS4 Antibody (PA5-115119) in ICC/IF
Immunocytochemistry analysis of DHRS4 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115119) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115119
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DHRS4(Accession Q9BTZ2), corresponding to amino acid residues C209-D259.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total DHRS4.
Target Information
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: carbonyl reductase; CR; DCR-AKL; dehydrogenase/reductase (SDR family) member 4; dehydrogenase/reductase (SDR family) member 4 like 2A; NADP-retinol dehydrogenase; NADPH-dependent carbonyl reductase; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; NDRD; NRDRB1; NRDRB2; peroxisomal short-chain alcohol dehydrogenase; PH PSCD; PHCR; SCAD-SRLp; short chain dehydrogenase/reductase family 25C member 2; short chain dehydrogenase/reductase family 25C, member 1; short-chain dehydrogenase/reductase family member 4; unnamed protein product
Gene Aliases: CR; D14Ucla2; mouNRDR; NDRD; NRDR; PHCR; PSCD; RRD; SCAD-SRL; SDR-SRL; SDR25C1; SDR25C2
UniProt ID: (Human) Q9BTZ2, (Rat) Q8VID1, (Mouse) Q99LB2
Entrez Gene ID: (Human) 10901, (Rat) 266686, (Mouse) 28200
3-keto sterol reductase activity
carbonyl reductase (NADPH) activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
alcohol dehydrogenase [NAD(P)+] activity
3-beta-hydroxy-5-beta-steroid dehydrogenase (NADP+) activity
identical protein binding
NADP-retinol dehydrogenase activity
retinal dehydrogenase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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