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Invitrogen
DYNC1H1 Polyclonal Antibody
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FIGURE: 1 / 5
DYNC1H1 Antibody (PA5-115149) in ICC/IF
Immunocytochemistry analysis of DYNC1H1 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115149) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115149
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DYNC1H1(Accession Q14204), corresponding to amino acid residues S2082-P2132.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total DYNC1H1.
Target Information
DYNC1H1 (Dynein Cytoplasmic 1 Heavy Chain 1) is a gene that encodes a protein belonging to the dynein family, which are motor proteins critical for various cellular processes. Dyneins are responsible for retrograde intracellular transport along microtubules, meaning they move cargo from the periphery of the cell towards the nucleus. The DYNC1H1 protein is a heavy chain component of cytoplasmic dynein 1, which plays a key role in the movement of organelles, vesicles, and other cellular components. Mutations in DYNC1H1 have been associated with several neurological disorders, including spinal muscular atrophy with lower extremity predominance (SMA-LED) and Charcot-Marie-Tooth disease type 2O (CMT2O). Research into DYNC1H1 continues to uncover its involvement in cellular mechanics and its implications in various genetic conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytoplasmic dynein heavy chain 1; dynein heavy chain, cytosolic; dynein heavy chain, retrograde transport; dynein, cytoplasmic, heavy chain 1; dynein, cytoplasmic, heavy polypeptide 1; legs at odd angle; MAP 1C; microtubule-associated protein 1 C; sprawling; unnamed protein product
Gene Aliases: 9930018I23Rik; CDCBM13; CMT2O; DHC1; DHC1a; DNCH1; Dnchc1; DNCL; Dnec1; DNECL; DYHC; HL-3; Loa; MAP1C; mKIAA0325; P22; SMALED1; Swl
UniProt ID: (Human) Q14204, (Mouse) Q9JHU4, (Rat) P38650
Entrez Gene ID: (Human) 1778, (Mouse) 13424, (Rat) 29489
cilium movement
microtubule-based movement
mitotic spindle organization
nuclear migration
retrograde axonal transport
cytoplasmic microtubule organization
positive regulation of intracellular transport
cytoplasmic mRNA processing body assembly
stress granule assembly
establishment of spindle localization
regulation of mitotic spindle organization
regulation of metaphase plate congression
positive regulation of cold-induced thermogenesis
positive regulation of spindle assembly
spermatid development
cellular response to 3,3',5-triiodo-L-thyronine
cellular response to nerve growth factor stimulus
positive regulation of mitotic cell cycle spindle assembly checkpoint
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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