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Invitrogen
IGFBP6 Polyclonal Antibody
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FIGURE: 1 / 3
IGFBP6 Antibody (PA5-115397) in ICC/IF
Immunocytochemistry analysis of IGFBP6 in A549 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115397). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115397
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human IGFBP6(Accession P24592), corresponding to amino acid residues R108-T158.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total IGFBP6.
Target Information
IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP6, which specifically inhibits IGF-II actions, is produced by bone cells and is the major IGF-BP present in cerebrospinal fluid. IGF-BP6 has been shown to inhibit IGF-II-dependent cancers such as neuroblastoma, colon cancer and rhabdomyosarcoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IBP-6; IGF binding protein 6; IGF-binding protein 6; IGFBP; IGFBP-6; IGFBP6; Insulin like growth factor binding protein; unnamed protein product
Gene Aliases: IBP6; IGF-BP6; RBP6A; RBP6G
UniProt ID: (Human) P24592, (Rat) P35572
Entrez Gene ID: (Human) 3489, (Rat) 25641
signal transduction
negative regulation of cell proliferation
cell migration
positive regulation of stress-activated MAPK cascade
positive regulation of MAPK cascade
regulation of insulin-like growth factor receptor signaling pathway
negative regulation of canonical Wnt signaling pathway
biological_process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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