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Invitrogen

CSF1R Polyclonal Antibody

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View all (93) CSF1R (CD115) antibodies

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CSF1R Polyclonal Antibody

Product Details

PA5-115557

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CSF1R(Accession P07333), corresponding to amino acid residues S716-M766.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900192

Product Specific Information

Antibody detects endogenous levels of total MCSF Receptor.

Target Information

CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: c-fms; CD115 antigen; CSF-1 receptor; CSF-1-R; CSFIR; EC 2.7.10.1; FMS proto-oncogene; kinase CSFR; macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; OTTHUMP00000224093; proto-oncogene c-Fms; proto-oncogene fms; transmembrane protein; unnamed protein product

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Gene Aliases: BANDDOS; C-FMS; CD115; CSF-1-R; CSF-1R; Csfmr; CSFR; Fim-2; FIM2; FMS; GPSC; HDLS; HDLS1; M-CSF-R; M-CSFR; mrfms

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UniProt ID: (Human) P07333, (Mouse) P09581

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Entrez Gene ID: (Human) 1436, (Rat) 307403, (Mouse) 12978

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity macrophage colony-stimulating factor receptor activity protein binding ATP binding growth factor binding protein phosphatase binding cytokine binding protein homodimerization activity
Process(es)
response to hypoxia microglial cell activation neutrophil homeostasis positive regulation of protein phosphorylation myeloid leukocyte differentiation response to ischemia response to stress transmembrane receptor protein tyrosine kinase signaling pathway axon guidance skeletal muscle tissue development cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation regulation of cell shape response to mechanical stimulus anatomical structure morphogenesis positive regulation of gene expression positive regulation of macrophage chemotaxis negative regulation of myotube differentiation microglia development skeletal muscle cell proliferation cell migration peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway telencephalon development dentate gyrus development olfactory bulb development forebrain neuron differentiation regulation of cell morphogenesis hemopoiesis osteoclast differentiation positive regulation of cell migration positive regulation of bone mineralization negative regulation of epithelial cell differentiation ruffle organization response to lipopolysaccharide positive regulation of chemokine production positive regulation of tumor necrosis factor production regulation of mononuclear cell proliferation regulation of actin cytoskeleton organization organ growth monocyte homeostasis cellular response to macrophage colony-stimulating factor stimulus macrophage colony-stimulating factor signaling pathway positive regulation of tyrosine phosphorylation of STAT protein negative regulation of apoptotic process regulation of MAPK cascade positive regulation by host of viral process regulation of bone resorption cell-cell junction maintenance positive regulation of osteoclast differentiation protein autophosphorylation response to axon injury positive regulation of lymphocyte proliferation positive regulation of multicellular organismal process myoblast proliferation positive regulation of protein kinase B signaling cardiac muscle cell proliferation positive regulation of protein tyrosine kinase activity microglial cell proliferation positive regulation of astrocyte activation positive regulation of ERK1 and ERK2 cascade positive regulation of leukocyte proliferation response to growth factor cellular response to cytokine stimulus cellular response to tumor necrosis factor cellular response to transforming growth factor beta stimulus positive regulation of macrophage proliferation positive regulation of cell cycle G1/S phase transition mononuclear cell differentiation negative regulation of platelet formation regulation of macrophage migration positive regulation of macrophage migration neuron projection extension positive regulation of cell motility positive regulation of myoblast proliferation inflammatory response signal transduction monocyte differentiation macrophage differentiation innate immune response animal organ development mammary gland duct morphogenesis
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