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Invitrogen
NOTCH4 Polyclonal Antibody
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FIGURE: 1 / 3
NOTCH4 Antibody (PA5-115664) in IHC (P)
Immunohistochemistry analysis of NOTCH4 in mouse lung tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115664) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115664
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NOTCH4(Accession Q99466), corresponding to amino acid residues R1474-G1524.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NOTCH4.
Target Information
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases (entrez gene).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAQB-143M3.4; FLJ16302; hNotch4; human homolog of Drosophila Notch; MGC74442; notch 4; Notch gene homolog 4; Notch homolog 4; NOTCH3; similar to Notch4; unnamed protein product
Gene Aliases: Int-3; INT3; N4
UniProt ID: (Human) Q99466, (Mouse) P31695
Entrez Gene ID: (Human) 4855, (Mouse) 18132, (Rat) 406162
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
patterning of blood vessels
morphogenesis of a branching structure
epithelial to mesenchymal transition
endothelial cell morphogenesis
vasculature development
regulation of transcription, DNA-templated
Notch signaling pathway
regulation of Notch signaling pathway
tissue development
regulation of gene expression
cell differentiation
mammary gland development
regulation of protein localization
endothelial cell differentiation
regulation of cell differentiation
negative regulation of endothelial cell differentiation
negative regulation of Notch signaling pathway
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
venous blood vessel morphogenesis
regulation of developmental process
positive regulation of developmental process
positive regulation of smooth muscle cell differentiation
negative regulation of cell adhesion molecule production
regulation of protein processing
positive regulation of aorta morphogenesis
negative regulation of cell-cell adhesion mediated by cadherin
luteolysis
cell fate determination
positive regulation of transcription of Notch receptor target
hemopoiesis
negative regulation of cell differentiation
positive regulation of transcription, DNA-templated
cell development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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