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Invitrogen
SMC2 Polyclonal Antibody
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FIGURE: 1 / 4
SMC2 Antibody (PA5-115930) in IHC (P)
Immunohistochemistry analysis of SMC2 in rat colorectal tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115930) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-115930
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SMC2(Accession O95347), corresponding to amino acid residues K930-G980.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SMC2.
Target Information
CAP-E and CAP-C (Chromosome Associated Protein-E & C) are also SMC (Structural Maintenance of Chromosome) family members that form a heterodimeric complex required for mitotic chromosome condensation to achieve proper segregation of genetic information during subsequent cell division. hCAP-C/hCAP-E is a component of a multiprotein complex called condensin that interacts with phosphorylation of Histone H3 resulting in the mitotic chromosome condensation. The distribution patterns of the two heterodimeric complexes in interphase nucleus indicate independent behavior of the two complexes during cell cycle. These results suggest that the two distinct complexes are involved in different aspects of mitotic chromosome organization in humar cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAP E; chromosome-associated protein E; FGF-inducible protein 16; fibroblast growth factor inducible 16; FIN16; FLJ10093; heterodimeric coiled-coil protein required for mitotic chromosome condensation; similar to X. laevis mitotic chromosome condensation protein XCAP-E, encoded by GenBank Accession Number U13674; SMC protein 2; SMC2 (structural maintenance of chromosomes 2, yeast)-like 1; SMC2 protein; SMC2 structural maintenance of chromosomes 2-like 1; structural maintenance of chromosomal proteins; hCAP-E; structural maintenance of chromosomes (SMC) family member; structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E; unnamed protein product; XCAP-E homolog
Gene Aliases: 5730502P04Rik; CAP-E; CAPE; Fin16; SMC-2; SMC2L1
UniProt ID: (Human) O95347, (Mouse) Q8CG48
Entrez Gene ID: (Human) 10592, (Mouse) 14211, (Rat) 362519
single strand break repair
nuclear division
mitotic chromosome condensation
meiotic chromosome condensation
cerebral cortex development
B cell differentiation
chromosome condensation
meiotic chromosome segregation
cell development
chromosome organization
meiotic cell cycle
kinetochore organization
positive regulation of chromosome segregation
immunoglobulin heavy chain V-D-J recombination
nuclear chromosome segregation
positive regulation of chromosome separation
positive regulation of chromosome condensation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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