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Invitrogen
UCP1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-116102
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human UCP1(Accession P25874), corresponding to amino acid residues A127-T177.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total UCP1.
Target Information
Mitochondrial uncoupling proteins are members of the family of mitochondrial anion carrier proteins. UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fat uncoupling protein; HGNC:12517; mitochondrial brown fat uncoupling protein 1-like; proton channel in the inner mitochondrial membrane; solute carrier family 25 member 7; thermogenin; UCP 1; uncoupling protein; uncoupling protein 1 (mitochondrial, proton carrier); uncoupling protein 1, mitochondrial; uncoupling protein, mitochondrial; unnamed protein product
Gene Aliases: SLC25A7; UCP; Ucpa; Uncp
UniProt ID: (Human) P25874, (Rat) P04633, (Mouse) P12242
Entrez Gene ID: (Human) 7350, (Rat) 24860, (Mouse) 22227
diet induced thermogenesis
generation of precursor metabolites and energy
regulation of transcription from RNA polymerase II promoter
mitochondrial transport
response to temperature stimulus
response to cold
response to nutrient levels
cellular response to hormone stimulus
cellular response to reactive oxygen species
brown fat cell differentiation
transmembrane transport
cellular response to cold
cellular response to fatty acid
positive regulation of cold-induced thermogenesis
hydrogen ion transmembrane transport
regulation of reactive oxygen species biosynthetic process
cellular response to dehydroepiandrosterone
mitochondrial transmembrane transport
adaptive thermogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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