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Invitrogen

Phospho-SERCA2 ATPase (Thr484) Polyclonal Antibody

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Product Details

PA5-117240

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.55 mg/mL

Amount

155 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2901870

Product Specific Information

Positive Samples: NIH/3T3, C6

Target Information

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; calcium ATPase; calcium pump 2; cardiac Ca2+ ATPase; endoplasmic reticulum class 1/2 Ca(2+) ATPase; HK1; HK2; non-muscle ATPase; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2; sarco/endoplasmic reticulum Ca2+-ATPase 2; SERCA; SERCA ATPase; SERCA-2b class 2; SR Ca(2+)-ATPase 2; unnamed protein product

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Gene Aliases: 9530097L16Rik; ATP2B; D5Wsu150e; DAR; DD; mKIAA4195; RHABDO2; SERCA2; Serca2a; SERCA2B; SercaII

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UniProt ID: (Human) P16615, (Rat) P11507, (Mouse) O55143

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Entrez Gene ID: (Human) 488, (Rat) 29693, (Mouse) 11938

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Function(s)
nucleotide binding calcium channel regulator activity calcium-transporting ATPase activity calcium ion binding protein binding ATP binding ATPase activity enzyme binding ion channel binding S100 protein binding calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential lncRNA binding lutropin-choriogonadotropic hormone receptor binding
Process(es)
autophagosome assembly muscle system process calcium ion transport cellular calcium ion homeostasis regulation of muscle contraction cell adhesion epidermis development positive regulation of heart rate regulation of cardiac muscle contraction by calcium ion signaling autophagosome membrane docking endoplasmic reticulum calcium ion homeostasis positive regulation of endoplasmic reticulum calcium ion concentration ion transmembrane transport response to endoplasmic reticulum stress relaxation of cardiac muscle sarcoplasmic reticulum calcium ion transport calcium ion transmembrane transport regulation of cardiac muscle cell membrane potential regulation of cardiac muscle cell action potential involved in regulation of contraction organelle localization by membrane tethering calcium ion transport from cytosol to endoplasmic reticulum regulation of cardiac conduction calcium ion import into sarcoplasmic reticulum regulation of the force of heart contraction ER-nucleus signaling pathway regulation of heart contraction positive regulation of cardiac muscle cell apoptotic process transition between fast and slow fiber cardiac muscle hypertrophy in response to stress response to lipopolysaccharide T-tubule organization cellular response to oxidative stress cellular response to heat negative regulation of heart contraction relaxation of skeletal muscle regulation of calcium ion-dependent exocytosis of neurotransmitter response to peptide hormone
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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