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Invitrogen

Phospho-IGF1R (Tyr1165, Tyr1166) Polyclonal Antibody

View all (69) IGF1R (CD221) antibodies

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Phospho-IGF1R (Tyr1165, Tyr1166) Polyclonal Antibody

Product Details

PA5-118536

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human IGF1R(Accession P08069), corresponding to amino acid residues around phosphorylated Tyr1165.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2903038

Product Specific Information

Antibody detects endogenous levels of IGF1 Receptor only when phosphorylated at Tyrosine 1165/Tyrosine 1166.

Target Information

IGF1R, also known as Insulin-like Growth Factor 1 (IGF-1) Receptor, is a receptor tyrosine kinase activated by IGF-1 and IGF-2. IGFR has been implicated in a variety of cancers. The protein is a tetramer consisting of two alpha, and two beta subunits. The alpha-subunits binds to insulin growth factor 1 with higher affinity than to insulin growth factor 2. Binding results in a conformational change, followed by autophosphorylation of IGF-1R at positions 1134, 1135, 1136. The activated IGF-1R in turn, causes phosphorylation of substrate proteins, followed by sequential activation of RAS, RAF, and mitogen-activated protein kinase isoforms ERK, p38, and JNK, leading to the transcription of genes that drive proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD221 antigen; IGF 1 receptor; IGF 1R; IGF-I receptor; Insulin like growth factor 1 receptor precursor; insulin-like growth factor I receptor; insulin-like growth factor-I receptor precursor; line 186; protein-tyrosine kinase (EC 2.7.1.112); type-I IGF receptor; unnamed protein product

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Gene Aliases: A330103N21Rik; CD221; D930020L01; hyft; IGF-1 receptor; IGF-1R; IGFIR; IGFIRC; IGFR; Igfr1; JTK13

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UniProt ID: (Human) P08069, (Mouse) Q60751, (Rat) P24062

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Entrez Gene ID: (Human) 3480, (Mouse) 16001, (Rat) 25718

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor-activated receptor activity insulin receptor binding structural molecule activity protein binding insulin-like growth factor binding ATP binding insulin-like growth factor I binding identical protein binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding G-protein alpha-subunit binding macromolecular complex binding protein transporter activity
Process(es)
protein phosphorylation immune response transmembrane receptor protein tyrosine kinase signaling pathway axonogenesis brain development positive regulation of cell proliferation insulin receptor signaling pathway epidermis development organ morphogenesis negative regulation of muscle cell apoptotic process cerebellum development establishment of cell polarity male sex determination adrenal gland development positive regulation of cell migration mammary gland development exocrine pancreas development neuron projection development positive regulation of cytokinesis cellular response to insulin stimulus positive regulation of osteoblast proliferation peptidyl-tyrosine autophosphorylation negative regulation of apoptotic process positive regulation of protein complex disassembly negative regulation of MAPK cascade positive regulation of MAPK cascade estrous cycle transcytosis response to ethanol positive regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of JNK cascade protein autophosphorylation insulin-like growth factor receptor signaling pathway positive regulation of developmental growth positive regulation of smooth muscle cell proliferation positive regulation of axon regeneration positive regulation of DNA metabolic process positive regulation of meiotic cell cycle positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling prostate gland epithelium morphogenesis cellular response to glucose stimulus cellular response to transforming growth factor beta stimulus positive regulation of steroid hormone biosynthetic process positive regulation of cell cycle process dendritic spine maintenance beta-amyloid clearance postsynaptic modulation of chemical synaptic transmission positive regulation of cold-induced thermogenesis response to L-glutamate negative regulation of hepatocyte apoptotic process negative regulation of cholangiocyte apoptotic process cellular response to beta-amyloid cellular response to insulin-like growth factor stimulus signal transduction protein kinase B signaling cellular response to oxygen-containing compound cardiac atrium development response to hormone hippocampus development response to nutrient levels response to insulin response to vitamin E cellular response to zinc ion starvation response to nicotine response to alkaloid cellular response to mechanical stimulus cellular response to estradiol stimulus cellular response to progesterone stimulus cellular response to testosterone stimulus cellular response to dexamethasone stimulus cellular senescence cellular response to aldosterone cellular response to angiotensin
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