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Invitrogen

Phospho-SRF (Thr159) Polyclonal Antibody

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Phospho-SRF (Thr159) Polyclonal Antibody

Product Details

PA5-118719

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human SRF(Accession P11831), corresponding to amino acid residues around phosphorylated Thr159.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2903219

Product Specific Information

Antibody detects endogenous levels of SRF only when phosphorylated at Thr159.

Target Information

Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF-binding sites are also constitutive promotor elements in many muscle-specific promotors. SFR is required for cardiac differentiation and maturation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-fos serum response element-binding transcription factor; minichromosome maintenance 1 homolog; OTTHUMP00000039820; serum response factor; serum response factor (c-fos serum response element-binding transcription factor); unnamed protein product

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Gene Aliases: MCM1; RGD1559787

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UniProt ID: (Human) P11831, (Mouse) Q9JM73

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Entrez Gene ID: (Human) 6722, (Rat) 501099, (Mouse) 20807

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding serum response element binding chromatin DNA binding protein homodimerization activity histone deacetylase binding sequence-specific DNA binding protein dimerization activity RNA polymerase II sequence-specific DNA binding transcription factor binding primary miRNA binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding
Process(es)
patterning of blood vessels response to hypoxia in utero embryonic development mesoderm formation neuron migration trophectodermal cell differentiation heart looping morphogenesis of an epithelial sheet cell migration involved in sprouting angiogenesis leukocyte differentiation regulation of transcription, DNA-templated actin filament organization cell-matrix adhesion gastrulation heart development long-term memory negative regulation of cell proliferation associative learning response to hormone epithelial structure maintenance hippocampus development tangential migration from the subventricular zone to the olfactory bulb actin cytoskeleton organization contractile actin filament bundle assembly regulation of cell adhesion platelet activation platelet formation negative regulation of cell migration thyroid gland development forebrain development neuron projection development response to cytokine megakaryocyte development dorsal aorta morphogenesis wound healing stress fiber assembly skin morphogenesis positive thymic T cell selection sarcomere organization positive regulation of cell differentiation positive regulation of axon extension positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle contraction positive regulation of transcription by glucose muscle cell cellular homeostasis thymus development developmental growth erythrocyte development positive regulation of filopodium assembly cardiac myofibril assembly hematopoietic stem cell differentiation positive regulation of transcription initiation from RNA polymerase II promoter long term synaptic depression face development heart trabecula formation cardiac muscle cell myoblast differentiation lung morphogenesis bronchus cartilage development trachea cartilage development cardiac vascular smooth muscle cell differentiation eyelid development in camera-type eye lung smooth muscle development establishment of skin barrier bicellular tight junction assembly cellular response to glucose stimulus primitive streak formation epithelial cell-cell adhesion cellular senescence cell-cell adhesion negative regulation of beta-amyloid clearance negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter response to toxic substance neuron development regulation of smooth muscle cell differentiation angiogenesis involved in wound healing
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