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Invitrogen
BOK Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-120442
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BOK (NP_115904.1).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.79 mg/mL
Amount
79 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: Mouse brain, Rat testis. The target is usually found in the following locations: Endoplasmic reticulum membrane, Golgi apparatus membrane, Single-pass membrane protein.
Immunogen sequence: MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERAAPVP GRLAEVCAVL LRLGDELEMI RPSVYRNVAR QLHISLQSEP
Target Information
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains all four BCL-2 like domains and is a pro-apoptotic BCL-2 protein identified in the ovary.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a member of Bcl-2 family; alternatively spliced variant; truncated BH3 domain; apoptosis activator Mtd; bcl-2-like protein 9; BCL2 family apoptosis regulator; BCL2 related ovarian killer; bcl2-L-9; BCL2-related ovarian killer; BOK, BCL2 family apoptosis regulator; hBOK; unnamed protein product
Gene Aliases: BCL2L9; Bok-BH3; BOKL; matador; mtd
UniProt ID: (Human) Q9UMX3, (Mouse) O35425, (Rat) Q792S6
Entrez Gene ID: (Human) 666, (Mouse) 51800, (Rat) 29884
release of cytochrome c from mitochondria
apoptotic process
cellular component disassembly involved in execution phase of apoptosis
male gonad development
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of autophagy
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
oligodendrocyte differentiation
protein oligomerization
neuron apoptotic process
regulation of cytosolic calcium ion concentration
negative regulation of mitochondrial depolarization
transmembrane transport
negative regulation of necroptotic process
intrinsic apoptotic signaling pathway by p53 class mediator
response to cisplatin
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of execution phase of apoptosis
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of chorionic trophoblast cell proliferation
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of PERK-mediated unfolded protein response
regulation of granulosa cell apoptotic process
positive regulation of intrinsic apoptotic signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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