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Invitrogen

Phospho-SMO (Ser616) Polyclonal Antibody

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Phospho-SMO (Ser616) Polyclonal Antibody

Product Details

PA5-121319

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-

Dot blot (DB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic phosphorylated peptide around S616 of human SMO (NP_005622.1).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.95 mg/mL

Amount

95 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2914891

Product Specific Information

The target is usually found in the following locations: Cell projection, Membrane, Multi-pass membrane protein, cilium.

Immunogen sequence: VSSAW

Target Information

Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: candidate receptor for sonic hedgehog; frizzled family member 11; HGNC:11119; Protein Gx; Protein SMOH; Protein smoothened; seven transmembrane helix receptor; smoothened homolog; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor

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Gene Aliases: CRJS; FZD11; Gx; PHLS; SMO; SMOH

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UniProt ID: (Human) Q99835

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Entrez Gene ID: (Human) 6608

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Function(s)
cAMP-dependent protein kinase inhibitor activity transmembrane signaling receptor activity G-protein coupled receptor activity patched binding protein binding oxysterol binding protein kinase A catalytic subunit binding protein sequestering activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter ossification vasculogenesis osteoblast differentiation in utero embryonic development cell fate specification neural crest cell migration negative regulation of protein phosphorylation hair follicle development heart looping positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation heart morphogenesis determination of left/right asymmetry in lateral mesoderm type B pancreatic cell development protein import into nucleus apoptotic process signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway smoothened signaling pathway determination of left/right symmetry ventral midline determination pattern specification process neuroblast proliferation central nervous system development midgut development cell proliferation positive regulation of cell proliferation tissue development anterior/posterior pattern specification dorsal/ventral pattern formation gene expression regulation of gene expression positive regulation of gene expression negative regulation of gene expression spinal cord dorsal/ventral patterning dentate gyrus development cerebellar cortex morphogenesis thalamus development dorsal/ventral neural tube patterning central nervous system neuron differentiation cerebral cortex development positive regulation of cell migration epithelial cell differentiation negative regulation of epithelial cell differentiation hair follicle morphogenesis protein localization to nucleus multicellular organism growth positive regulation of multicellular organism growth positive regulation of protein import into nucleus odontogenesis of dentin-containing tooth negative regulation of apoptotic process negative regulation of DNA binding positive regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of organ growth astrocyte activation cell development digestive tract development embryonic organ development developmental growth skeletal muscle fiber development smooth muscle tissue development forebrain morphogenesis homeostasis of number of cells within a tissue epithelial cell proliferation positive regulation of epithelial cell proliferation protein stabilization myoblast migration negative regulation of hair follicle development contact inhibition atrial septum morphogenesis mammary gland epithelial cell differentiation epithelial-mesenchymal cell signaling somite development pancreas morphogenesis left/right axis specification cellular response to cholesterol dopaminergic neuron differentiation commissural neuron axon guidance mesenchymal to epithelial transition involved in metanephric renal vesicle formation positive regulation of branching involved in ureteric bud morphogenesis response to inositol regulation of somatic stem cell population maintenance regulation of heart morphogenesis
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