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Invitrogen

Phospho-PKC delta (Ser645) Polyclonal Antibody

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Phospho-PKC delta (Ser645) Polyclonal Antibody

Product Details

PA5-121325

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic phosphorylated peptide around S645 of human PKC delta (NP_006245.2).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.87 mg/mL

Amount

87 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2914897

Product Specific Information

Positive test controls include: 293T. The target is usually found in the following locations: Cell membrane, Cytoplasm, Endoplasmic reticulum, Mitochondrion, Nucleus, Peripheral membrane protein, perinuclear region.

Immunogen sequence: RLSYS

Target Information

The PKC family of serine/threonine kinases, including PRKCD (PKC delta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1-May; alternatively spliced; kinase nPKC-delta; KPCD; nPKC-delta; PKCdelta; PKCdeltaVIII; protein kinase C delta subspecies; protein kinase C delta VIII; protein kinase C, delta IV; protein kinase C, delta V; protein kinase C[d]; tyrosine-protein kinase PRKCD; unnamed protein product

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Gene Aliases: ALPS3; CVID9; D14Ertd420e; MAY1; nPKC-delta; PKC[d]; PKCD; PKCdelta

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UniProt ID: (Human) Q05655, (Mouse) P28867, (Rat) P09215

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Entrez Gene ID: (Human) 5580, (Mouse) 18753, (Rat) 170538

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein kinase C activity calcium-dependent protein kinase C activity calcium-independent protein kinase C activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding enzyme activator activity enzyme binding protein kinase binding protein tyrosine kinase activator activity insulin receptor substrate binding protein serine kinase activity TIR domain binding protein serine/threonine kinase binding
Process(es)
protein phosphorylation apoptotic process cellular response to DNA damage stimulus signal transduction intrinsic apoptotic signaling pathway in response to oxidative stress peptidyl-serine phosphorylation peptidyl-threonine phosphorylation termination of signal transduction negative regulation of actin filament polymerization positive regulation of superoxide anion generation regulation of actin cytoskeleton organization negative regulation of glial cell apoptotic process cellular response to UV intracellular signal transduction Fc-gamma receptor signaling pathway involved in phagocytosis neutrophil activation positive regulation of protein import into nucleus defense response to bacterium negative regulation of apoptotic process negative regulation of MAPK cascade regulation of mRNA stability positive regulation of DNA repair negative regulation of smoothened signaling pathway negative regulation of insulin receptor signaling pathway negative regulation of inflammatory response protein stabilization positive regulation of DNA metabolic process negative regulation of filopodium assembly cell chemotaxis cellular response to hydrogen peroxide protein kinase C signaling cellular response to fatty acid cellular response to hydroperoxide negative regulation of platelet aggregation cellular senescence phospholipase C/protein kinase C signal transduction positive regulation of phospholipid scramblase activity cellular response to angiotensin regulation of ceramide biosynthetic process positive regulation of ceramide biosynthetic process positive regulation of glucosylceramide catabolic process positive regulation of sphingomyelin catabolic process response to oxidative stress immunoglobulin mediated immune response collagen metabolic process cellular response to oxidative stress B cell proliferation regulation of phosphorylation positive regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade post-translational protein modification positive regulation of glucose import protein autophosphorylation D-aspartate import regulation of platelet aggregation positive regulation of apoptotic signaling pathway response to hypoxia response to xenobiotic stimulus response to mechanical stimulus response to glucose cellular response to insulin stimulus cellular response to glucose starvation response to hydrogen peroxide response to amino acid response to ethanol response to phorbol 13-acetate 12-myristate
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