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Invitrogen
Phospho-TSC2 (Ser1798) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-TSC2 (Ser1798) Antibody (PA5-12908) in ICC/IF
Immunocytochemistry analysis of Phospho-TSC2 (Ser1798) in MCF-7 cells. Samples were incubated in Phospho-TSC2 (Ser1798) polyclonal antibody (Product # PA5-12908) followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-12908
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1798 of human TSC2
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.50 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2), is implicated as a tumor suppressor and may function in vesicular transport, play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Phosphorylation of tuberin on Ser 939 and Thr 1462 regulates its interaction with hamartin, and is stimulated by various growth factors through the phosphoinositide 3-kinase/Akt pathway. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. TSC2 specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors and are involved in diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma. Alternative splicing results in transcript variants of three different isoforms of TSC2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000198394; protein phosphatase 1, regulatory subunit 160; tuberous sclerosis 2 protein; tuberous sclerosis complex locus 2; unnamed protein product
Gene Aliases: LAM; PPP1R160; TSC4
UniProt ID: (Human) P49815
Entrez Gene ID: (Human) 7249
neural tube closure
protein import into nucleus
endocytosis
small GTPase mediated signal transduction
heart development
protein localization
negative regulation of cell proliferation
cellular response to starvation
vesicle-mediated transport
positive regulation of macroautophagy
regulation of macroautophagy
regulation of endocytosis
negative regulation of TOR signaling
anoikis
regulation of insulin receptor signaling pathway
positive chemotaxis
regulation of small GTPase mediated signal transduction
regulation of cell cycle
negative regulation of protein kinase B signaling
negative regulation of macromitophagy
negative regulation of TORC1 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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