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Invitrogen
Phospho-TBK1 (Ser172) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-TBK1 (Ser172) Antibody (PA5-13056) in DB
Dot blot analysis of Phospho-TBK1 (Ser172). Samples were incubated with Phospho-TBK1 (Ser172) polyclonal antibody (Product # PA5-13056) using a dilution of 0.5 µg/mL. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed on nitrocellulose membrane.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-13056
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S172 of human TBK
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with mouse and Xenopus based on sequence homology.
Target Information
TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKK beta, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKK beta through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ11330; NF-kappa-B-activating kinase; NF-kB-activating kinase; protein kinase; tbk; unnamed protein product
Gene Aliases: AIARV; FTDALS4; IIAE8; NAK; T2K
UniProt ID: (Human) Q9UHD2
Entrez Gene ID: (Human) 29110
activation of innate immune response
cytoplasmic pattern recognition receptor signaling pathway
protein phosphorylation
defense response
inflammatory response
I-kappaB kinase/NF-kappaB signaling
response to virus
positive regulation of autophagy
negative regulation of gene expression
macroautophagy
positive regulation of macroautophagy
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of TOR signaling
regulation of type I interferon production
positive regulation of type I interferon production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
toll-like receptor 4 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
response to other organism
type I interferon signaling pathway
positive regulation of type I interferon-mediated signaling pathway
T follicular helper cell differentiation
antiviral innate immune response
cGAS/STING signaling pathway
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
positive regulation of xenophagy
positive regulation of TORC2 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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