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Invitrogen

BRG1 Polyclonal Antibody

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BRG1 Polyclonal Antibody

Product Details

PA5-141072

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide within human BRG1 aa 200-300/1647.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 50% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2932524

Target Information

Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-dependent helicase SMARCA4; brahma protein-like 1; BRG1-associated factor 190A; BRM/SWI2-related gene 1; FLJ39786; global transcription activator homologous sequence; homeotic gene regulator; mitotic growth and transcription activator; N-terminal region of the protein; nuclear protein GRB1; protein brahma homolog 1; protein BRG-1; SNF2-beta; SNF2-like 4; sucrose nonfermenting-like 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; transcription activator BRG1; unnamed protein product

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Gene Aliases: b2b508.1Clo; b2b692Clo; BAF190; BAF190A; BRG1; CSS4; HP1-BP72; hSNF2b; MRD16; OTSC12; RTPS2; SNF2; SNF2-beta; SNF2beta; SNF2L4; SNF2LB; SW1/SNF; SWI2

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UniProt ID: (Human) P51532, (Mouse) Q3TKT4

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Entrez Gene ID: (Human) 6597, (Mouse) 20586

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase I CORE element sequence-specific DNA binding transcription cofactor binding p53 binding DNA binding chromatin binding transcription coactivator activity transcription corepressor activity helicase activity protein binding ATP binding DNA-dependent ATPase activity ATPase activity Tat protein binding nucleosomal DNA binding histone binding identical protein binding androgen receptor binding DNA polymerase binding lncRNA binding ATP-dependent chromatin remodeler activity nucleosome array spacer activity macromolecular complex binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter RNA polymerase I preinitiation complex assembly neural retina development chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nervous system development positive regulation of cell proliferation regulation of mitotic metaphase/anaphase transition positive regulation of Wnt signaling pathway negative regulation of cell growth heterochromatin assembly positive regulation by host of viral transcription positive regulation of T cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation positive regulation of myoblast differentiation positive regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of androgen receptor signaling pathway regulation of G0 to G1 transition positive regulation of cold-induced thermogenesis positive regulation of signal transduction by p53 class mediator positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter positive regulation of stem cell population maintenance positive regulation of glucose mediated signaling pathway positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of G1/S transition of mitotic cell cycle positive regulation of double-strand break repair regulation of nucleotide-excision repair cell morphogenesis blood vessel development vasculogenesis in utero embryonic development blastocyst growth blastocyst hatching liver development outflow tract morphogenesis ventricular septum development nucleosome assembly nucleosome disassembly glial cell fate determination heart development gene expression oligodendrocyte development stem cell population maintenance neurogenesis extracellular matrix organization keratinocyte differentiation regulation of cell migration forebrain development hindbrain development positive regulation of myelination positive regulation of macrophage fusion embryonic hindlimb morphogenesis aortic smooth muscle cell differentiation aorta development negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of cell size embryonic organ morphogenesis epidermis morphogenesis definitive erythrocyte differentiation heart trabecula formation coronary vasculature development pharyngeal arch artery morphogenesis lens fiber cell development negative regulation of reactive oxygen species biosynthetic process
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