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Invitrogen
Phospho-CD244 (Tyr271) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-CD244 (Tyr271) Antibody (PA5-141977) in IP
Immunoprecipitation analysis of CD244 in lysates of Human Natural Killer cells with (+) or without (-) pervanadate treatment of the cells using Phospho-CD244 (Tyr271) Polyclonal Antibody (Product # PA5-141977) at 2 µg/mL. Primary incubation was 1 hour. Detected by chemiluminescence. Data kindly provided by Dr Nicholas G Clarkson, Sir William Dunn School of Pathology, Oxford, UK.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-141977
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-EFLTIpYEDVKD.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternatively spliced; CD244 molecule, natural killer cell receptor 2B4; cell surface glycoprotein; immunoglobulin superfamily; h2B4; NK cell activation inducing ligand NAIL; NK cell activation-inducing ligand; NK cell type I receptor protein 2B4; NKR Nmrk; signaling lymphocytic activation molecule 4; SLAM family member 4; unnamed protein product
Gene Aliases: 2B4; NAIL; NKR2B4; Nmrk; SLAMF4
UniProt ID: (Human) Q9BZW8
Entrez Gene ID: (Human) 51744
natural killer cell activation involved in immune response
immune response
signal transduction
natural killer cell activation
positive regulation of interferon-gamma production
positive regulation of interleukin-8 production
positive regulation of inositol phosphate biosynthetic process
positive regulation of granzyme B production
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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