Search
Invitrogen
REST Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-143238
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-PETPGAEDKGKSSK.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: neural-restrictive silencer factor; neuron restrictive silencer factor; repressor binding to the X2 box; transcription factor
Gene Aliases: DFNA27; GINGF5; HGF5; NRSF; WT6; XBR
UniProt ID: (Human) Q13127
Entrez Gene ID: (Human) 5978
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
regulation of alternative mRNA splicing, via spliceosome
response to hypoxia
response to ischemia
chromatin remodeling
regulation of transcription, DNA-templated
response to stress
positive regulation of gene expression
negative regulation of gene expression
negative regulation of aldosterone biosynthetic process
somatic stem cell population maintenance
positive regulation of programmed cell death
negative regulation by host of viral transcription
negative regulation of neuron differentiation
positive regulation of neuron differentiation
regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of calcium ion-dependent exocytosis
negative regulation of insulin secretion
negative regulation of neurogenesis
neurological system process
neuromuscular process controlling balance
detection of mechanical stimulus involved in sensory perception of sound
auditory receptor cell stereocilium organization
cardiac muscle cell myoblast differentiation
cellular response to electrical stimulus
cellular response to glucocorticoid stimulus
neuronal stem cell population maintenance
modification of synaptic structure
positive regulation of stem cell population maintenance
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of cortisol biosynthetic process
negative regulation of dense core granule biogenesis
negative regulation of mesenchymal stem cell differentiation
negative regulation of amniotic stem cell differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support