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Invitrogen
VAV3 Polyclonal Antibody
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FIGURE: 1 / 1
VAV3 Antibody (PA5-143789) in WB
Western blot of VAV3 in human Jurkat (lanes 1 & 4), HUVEC (lanes 2 & 5), and A431 (lanes 3 & 6) cells. The blots were probed with anti-Vav2 (a.a. 309-322) at a dilution of 1:500 (lanes 1-3) and VAV3 polyclonal antibody (Product # PA5-143789) at a dilution of 1:500 (lanes 4-6).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-143789
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide (coupled to KLH) corresponding to amino acid residues in the Dbl homology domain of human Vav3. This sequence has high homology with similar regions in rat and mouse Vav3, and has low homology to other Vav family members.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects a 98 kDa* protein corresponding to the molecular mass of Vav3 on SDS-PAGE immunoblots of human Jurkat cells. The antibody also strongly detects an unidentified protein at 120 kDa in Jurkat and K562.
Target Information
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ40431; guanosine nucleotide exchange factor; putative signal transduction molecule; unnamed protein product; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3
Gene Aliases: A530094I06Rik; Idd18.1; RGD1565941
UniProt ID: (Human) Q9UKW4, (Mouse) Q9R0C8
Entrez Gene ID: (Human) 10451, (Rat) 295378, (Mouse) 57257
immune response-regulating cell surface receptor signaling pathway
vesicle fusion
cellular response to DNA damage stimulus
cell surface receptor signaling pathway
integrin-mediated signaling pathway
small GTPase mediated signal transduction
response to xenobiotic stimulus
cell migration
lamellipodium assembly
neutrophil chemotaxis
positive regulation of B cell proliferation
intracellular signal transduction
positive regulation of cell adhesion
B cell receptor signaling pathway
positive regulation of protein kinase B signaling
platelet activation
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of small GTPase mediated signal transduction
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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